进一步研究发现,Allo15CAR33-NKT/FG 细胞高表达 CXCR4 和 CCR5,这可能是其具有强骨髓归巢能力的原因。 6. 异体 CAR33-NKT 细胞可靶向髓系恶性肿瘤中骨髓驻留的白血病干细胞和祖细胞 在多种 AML 和 MDS 异体移植小鼠模型及原发性患者样本研究中,Allo15CAR33-NKT 细胞表现出强大的抗肿瘤疗效。在 THP1-FG、KG...
bone marrow cells (BMCs) derived from ten different AML patients with a substantial blast infiltration (>90% CD45dimAML blasts) were co-cultured for 4 h with CAR33-KLRC1ko-NK cells generated from different healthy donors (in totaln = 20 different donor preparations...
The conditioning therapy for patients receiving allo-HSCT from HLA haplo-identical donors for AML, ALL, and MDS is as follows: intravenous cytarabine (4 g/m2/day) on days − 10 to − 9 and intravenous ATG (2.5 mg/kg/day; Sang Stat, Lyon, France) on days − 5 to ...