Targeting CXCR4, SDF1, and β-adrenergic receptors in the AML microenvironment by novel antagonist POL6326, G-CSF, and isoproterenol. Blood. 2010;116:899–900.Chen, Y.; Zeng, Z.; Shi, Y.; Jacamo, R.; Ludin, C.; Dembowsky, K.; Frenette, P.; Konopleva, M.; Andreeff, M. ...
CXCR4 is overexpressed in a variety of cancers including chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), myeloma, lymphomas, and solid tumors [7]. CXCL12 (chemokine C-X-C motif ligand 12), also known as stromal cell-derived factor 1 (SDF-1), is CXCR4 sole ligand. It...
Advances in Radioligand Theranostics in Oncology 2024, Molecular Diagnosis and Therapy High-Contrast CXCR4-Targeted 18F-PET Imaging Using a Potent and Selective Antagonist 2021, Molecular Pharmaceutics Targeting CXCR4 in AML and ALL 2020, Frontiers in Oncology In vivo targeting of cxcr4—new horizons...
1i,j). This result was recapitulated in various breast and lung cancer cell lines, including MDA-MB-231, A431, NCI-H292, A549 and NCI-H358 cells. As with HER2, the maximum percent degradation was inversely related to the expression of CXCR7 relative to EGFR (R2 = 0.631; Fig. ...
A novel small molecule E-selectin inhibitor GMI-1271 blocks adhesion of AML blasts to E-selectin and mobilizes blood cells in Nodscid IL2Rgc−/− mice engrafted with human AML. Blood 120, 4092 (2012). Article Google Scholar DeAngelo, D. J. et al. High E-selectin ligand expression ...
It has also been shown that in AML, TGFβ/BMP2 signaling can inhibit the re-plating potential of cells transformed by HoxA9 deregulation. This is achieved via the binding of Smad 4, which blocks the ability of HoxA9 and its fusion protein Nup98-HoxA9 to target DNA sequences [77]....
[8]. FTO downregulates m6A levels, modulates the expression of Ankyrin Repeat and SOCS Box Containing 2 (ASB2) and Retinoic Acid Receptor Alpha (RARA), enhances gene-mediated cell transformation and leukemia onset, and inhibits acute myeloid leukemia (AML) cell differentiation [9]. In summary,...
(HIF1), C-X-C motif chemokine 4 (CXCR4) and Hypoxia‐inducible glycolytic enzyme hexokinase‐2 (HK2) amongst many others. They work by affecting different mechanisms including influencing angiogenesis, treatment resistance, immune surveillance and the ability to metastasize all of which contribute ...
TGF-β-neutralizing antibody 1D11 enhances cytarabine-induced apoptosis in AML cells in the bone marrow microenvironment. PLoS ONE 8, e62785 (2011). Article CAS Google Scholar Dituri, F. et al. Differential inhibition of the TGF-β signaling pathway in HCC cells using the small molecule ...
PC: pancreatic cancer, LC: lung cancer, PCa: Prostate cancer, CRC: Colorectal cancer, GBM: glioblastoma, OS: Osteosarcoma, AML: Acute myelocytic leukemia Full size image Genomic information and basic function of METTLs METTL1 Methyltransferase-like 1 (METTL1) is located in the (12q13-14) ...