In this study, activating and inhibitory receptor expressions and interleukin (IL)-22 levels of NK cells were investigated in RR-MS patients with or without IFN-beta therapy. Activating receptor expression and IL-22 levels of NK cells were increased in RR-MS patients under IFN-beta therapy. ...
对近些年的研究进行总结和整理,发现CD3和CD28的协同免疫性,通常是研究的一个关键点。其中将CD3单抗与CD28单抗联用可以促进一些免疫细胞的增殖,同时提高免疫细胞对肿瘤的杀伤能力。既兼具T淋巴细胞的抗肿瘤活性同时保留了NK细胞的非MHC限制性的对肿瘤细胞的杀伤作用 ...
NATURAL killer (NK) cells are large granular lymphocytes capable of killing tumour cells in a non-MHC restricted manner 1,2 . NK cells do not express cell-surface CD3, or any known target recognition structure analogous to the T cell antigen receptor (TCR) heterodimers (αβ or γδ) 3–...
CD3AK(Anti-CD3 Antibody induced activated killer cells)是抗CD3单克隆抗体和IL-2共同激活的杀伤细胞,具有强体外增殖能力、高效细胞毒活性。是继LAK、TIL细胞后又一具有杀伤肿瘤作用的免疫活性细胞,与LAK细胞及TIL细胞相比较,CD3AK细胞具有扩增能力强、体外存活时间较长、细胞毒活性高、分泌淋巴因子的能力强和体内外...
Keywords:Naturalkillercells:Anti—CD3antibodies;Interleukin一2;Adoptiveimmunotheraphy 摘 要:目的 探索从人PBMC中高效扩增细胞毒性CD3一CD56 NK细胞的方法。方法 使用干细胞 生长培养基(SCGM)和RPMI1640培养基,在抗CD3单抗、IL一2和植物血凝素(PHA)的作用下从5例健 ...
CD3- CD16-CD56bright immunoregulatory NK Cells are increased in the tumor microenvironment and inversely correlate with advanced stages in pa- tients with ... F Gogali,G Paterakis,GZ Rassidakis,... - 《Thyroid》 被引量: 0发表: 2013年 Role of CD4(+) CD25(+) regulatory T cells in T ...
The CD3- 16+ 56+ NK cell count independently predicts autologous blood stem cell mobilization.Antigens, CD3Killer Cells, NaturalCOUNTAutologousBloodHematopoietic Stem Cell Mobilization抗原, CD3杀伤细胞, 天然血液造血干细胞动员Better predictive factors for autologous blood stem cell mobilization (BSCM) are...
关键词: NK细胞 / 抗CD3单抗 / IL-2 / 过继免疫治疗 Abstract: Objective To study the expanding way of human cytotoxic CD3-CD56+ NK cells from peripheral blood mononuclear cells PBMC. Methods PBMCs were cultured in stem cell growth medium SCGM or RPMI 1640 supplemented with monoclonal anti-CD...
NK cells[(16.7±4.8)%],inthesurroundingtissueofHCCweresignificantlylowerthanfardistancinghepato— cellularcarcinomagroup[(22.04-4.4)%]、chronichepatitis/hepaticcirhosisgroup[(13.4±1.3)%],and normalcontrolgroup[(35.1±7.2)%](t=2.301,2.137,2.034,P<0.05).CD3‘CD161 ...
NKp461+CD3+ cells: A novel nonconventional T cell subset in cattle exhibiting both NK cell and T Cell features NKp46+ CD3+ cells: a novel nonconventional T cell subset in cattle exhibiting both NK cell and T cell features. J Immunol. 2014;192(8):3868-80... Storset,K A.,Hope,......