CD20+T细胞淋巴瘤/白血病(ATLL)病例系列研究显示,它们可能发生在儿童或成人中,往往与侵袭性病程有关,并且可能与人嗜T淋巴细胞病毒(HTLV)有关。 简评:将免疫细胞亚群进行不断细分,很多时候是为了增加对疾病的理解,为未来的治疗提供更多的基础。 参考资料 利妥昔单抗注射液说明书...
^+BcellswhichrepresentthemajorityofcellsexpressingCD20(Hultinetal.;1993).TheamountoftheCD20antigenhasbeenassessedtobe25to50timeshigheronCD20^+CD19^+BcellscomparedtoCD20^+CD3^+Tcells(Hultinetal.;1993).AtfirstdescriptionofthiscellpopulationthefrequencyoftheseCD20^+Tcellshasbeendescribedtorepresentanaverageof...
第二款CD20抗体到达Roche大本营。 T-cell engager:Mosunetuzumab 双特异性抗体的概念由来已久,甚至早于杂交瘤技术(1975年)。1961年,研究者将A和B两种抗体用胃蛋白酶消化,得到(Fab)2,然后将两种(Fab)2混在一起先后进行还原和氧化处理,得到包含AB-Fab双特异性抗体在内的混合物。 BiTE是经典的T-cell engager双...
[10] Schneider, Dina, et al. "Trispecific CD19-CD20-CD22–targeting duoCAR-T cells eliminate antigen-heterogeneous B cell tumors in preclinical models." Science Translational Medicine 13.586 (2021): eabc6401.[11] Grandjean, Capucine L., et al. "Imaging the mechanisms of anti-CD20 therapy ...
其专注于免疫细胞疗法,通过增压选择的 oNK 细胞和 γδ (γδ) T 细胞,和利用抗体-细胞偶联 (ACC) 技术结合新颖且成熟的靶向机制,来靶向癌细胞。 育世博管线 参考来源: [1] https://www.acepodia.com/about/ [2]The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy...
本研究表明,CD20 CAR-T细胞治疗利妥昔单抗-R/R CD20+B-NHL患者是可行和有效的。患者最佳疗效ORR为100%,未达到中位PFS和OS,中位CR持续时间超过6个月。结合既往其他研究的结果,本研究为CD20 CAR-T细胞治疗NHL患者提供了进一步的支持...
T cells in multiple sclerosis: implications for treatment with ocrelizumab Features of CD20+ T cells: CD20 is a membrane-spanning hosphopro-tein strongly expressed on the cell surface of B lineage cells and is widely regarded as a B cell specific marker. However, CD20 (Figure 1) is also ...
[10] Schneider, Dina,et al."Trispecific CD19-CD20-CD22–targeting duoCAR-T cells eliminate antigen-heterogeneous B cell tumors in preclinical models." Science Translational Medicine 13.586 (2021): eabc6401. [11] Grandjean, Capucine L.,et al."Imaging the mechanisms of anti-CD20 therapy in viv...
Furthermore, immunofluorescence studies detected a close association between human plasma cells and T cells in vivo. These data reveal that human tonsil contains long-lived plasma cells, the majority of which express CD20 and can be deleted with anti-CD20 therapy. In addition, an important role ...
The CD20 molecule was evaluated as a B-cell lymphoma target epitope for T cells expressing a CD20-specific single-chain FvFc-zeta (scFvFc:zeta) chimeric receptor. A cDNA construct consisting of a murine kappa leader sequence, CD20-specific scFv, human immunoglobulin (Ig) G1 hinge-C(H)2-C...