T-cell malignancies are associated with frequent relapse and high morbidity, which is partly due to the lack of effective or targeted treatment options. To broaden the use of CAR-T cells in pan T-cell malignancies, we developed an allogeneic "universal" CD2-targeting CAR-T cell (UCART2), ...
CD2与其配体CD58之间的相互作用已被证明对CD19 CAR-T细胞杀死肿瘤细胞发挥重要作用,而CD58在淋巴瘤细胞上的表达缺失与接受CD19 CAR-T治疗的患者的耐药性和复发相关。因此,与CD3双特异性相比,通过PIT565共刺激CD2可能会克服T细胞衰竭,增加患者反应的深度和持续时间。 临床前研究结果也表明,与CD3双特异性相比,PIT565...
Human T cell activation and expansion reagent Request Pricing Product Advantages Robust activation and expansion of human T cells without the use of magnetic beads, feeder cells, or antigen Provides a gentle activation stimulus that maintains high viability of activated and expanded T cells ...
该方法通过(a)将抗cd2抗体药物缀合物(adc)施用至患有癌症或自身免疫性疾病的人类受试者,其中抗cd2adc包含经由接头与细胞毒素缀合的抗cd2抗体或其抗原结合片段;以及(b)将治疗有效量的表达car的免疫细胞施用至人类受试者,其中car包含与肿瘤抗原或与自身免疫性疾病相关的抗原结合...
signals to T cells, suggesting that it has critical clinical implications in anti-TIGIT therapy. The loss of CD58, a ligand of CD2, is often observed in tumors resistant to ICIs or CAR T-cell therapies, highlighting the importance of the CD2‒CD58 axis in regulating T-cell antitumor ...
迄今为止,成功的CAR-T细胞治疗都与用病毒载体工程化的T细胞有关。然而,复发、制造过程的复杂性以及这些技术在包括实体瘤在内的其他疾病中的应用,需要更复杂的设计和基因转移技术来适应这些挑战。为了填补这些空白,非病毒技术正在不断取得进展,并正在改写CAR-T疗法的...
今年沃伦·阿尔珀特奖授予了4位CAR-T先驱。 “今年获奖的4位科学家的集体工作,推动了血液癌症治疗进入免疫治疗的新时代”。阿尔珀特基金会主席、哈佛医学院院长George Daley表示。 推进血液癌治疗进入新时代 2024年,沃伦·阿尔珀特基金会奖授予...
Sharma A, Tilak T, Bakhshi S, Raina V, Kumar L, Chaudhary S, et al. Lactobacillus brevis CD2 lozenges prevent oral mucositis in patients undergoing high dose chemotherapy followed by haematopoietic stem cell transplantation. ESMO Open. 2016;1(6):e000138. PubMed Google Scholar Tasli L, Mat...
CD2相比CD28和4-1BB作为免疫共刺激还有一个很大的优势,EvolveImmune基于公开发表的数据分析过肿瘤中TILs细胞表达CD2,CD28和4-1BB的比例,结果发现,CD2在CD4T和CD8T细胞表达阳性率平均可以达到70%左右,CD28在CD4T细胞表达阳性率约30%左右,CD28在CD8T细胞表达阳性率只有约20%,而4-1BB就最少了,在两种T细胞亚型上表...
The CaPdMg2, SrPdMg2 and CaRhIn2 structures are all derived from a CaIn2-related subcell by an ordered filling of transition metal atoms into trigonal prisms. This leads to different herringbone patterns for the networks of puckered and elongated hexagons of magnesium and indium atoms. CaTMg2...