T-cell malignancies are associated with frequent relapse and high morbidity, which is partly due to the lack of effective or targeted treatment options. To broaden the use of CAR-T cells in pan T-cell malignancies, we developed an allogeneic "universal" CD2-targeting CAR-T cell (UCART2), ...
CD2与其配体CD58之间的相互作用已被证明对CD19 CAR-T细胞杀死肿瘤细胞发挥重要作用,而CD58在淋巴瘤细胞上的表达缺失与接受CD19 CAR-T治疗的患者的耐药性和复发相关。因此,与CD3双特异性相比,通过PIT565共刺激CD2可能会克服T细胞衰竭,增加患者反应的深度和持续时间。 临床前研究结果也表明,与CD3双特异性相比,PIT565...
然而通用型CAR-T仍面临技术瓶颈和临床应用挑战,最主要的挑战是异体T细胞引发的宿主免疫排斥可能影响疗效持久性,需通过基因编辑技术进一步优化。 近日,华中科技大学同济医学院附属同济医院周剑峰/王珏团队、南京驯鹿生物技术股份有限公司(驯鹿生物)胡广/张佳元团队、中国医学...
Human T cell activation and expansion reagent Request Pricing Product Advantages Robust activation and expansion of human T cells without the use of magnetic beads, feeder cells, or antigen Provides a gentle activation stimulus that maintains high viability of activated and expanded T cells ...
迄今为止,成功的CAR-T细胞治疗都与用病毒载体工程化的T细胞有关。然而,复发、制造过程的复杂性以及这些技术在包括实体瘤在内的其他疾病中的应用,需要更复杂的设计和基因转移技术来适应这些挑战。为了填补这些空白,非病毒技术正在不断取得进展,并正在改写CAR-T疗法的...
signals to T cells, suggesting that it has critical clinical implications in anti-TIGIT therapy. The loss of CD58, a ligand of CD2, is often observed in tumors resistant to ICIs or CAR T-cell therapies, highlighting the importance of the CD2‒CD58 axis in regulating T-cell antitumor ...
在一种实施方案中,抗cd2adc在car-t疗法的施用之前施用至人类患者。可以与本文描述的抗cd2adc疗法组合使用的car-t细胞的实例包括但不限于cd19car-t(例如,cart-19-01,02,03(fujianmedicaluniversity);daopeicart(hebeisenlangbiotechnologyinc.);im19cart/001,ymcart201702(beijingimmunochinamedicalscience&technologyco...
艾伯维联手Genmab(GMAB)打造的抗CD3和CD20双功能抗体Epcoritamab治疗骨髓瘤获美FDA授予的突破治疗地位!Epcoritamab同时结合T细胞表面的CD3和癌细胞表面的CD20,把T细胞和癌细胞链接在一起直接杀死癌细胞,作用机制很像CAR-T;Epcoritamab现有适应症是复发/难治性滤泡性淋巴瘤(FL),此外,欧盟医药管理已受理Epcoritamab同...
该适应症是该公司在自免疾病领域申请的首个创新药管线。 SLE是一种慢性、多器官系统受累的自身免疫性疾病,被称为“不死的癌症”,影响着我国上百万国民的健康和生活质量,尤其是20至40岁育龄期女性。 随着CAR-T在自免领域的成功应用,预期将成为SLE治疗的重要手段,改善SLE患者的治疗困境。
The CaPdMg2, SrPdMg2 and CaRhIn2 structures are all derived from a CaIn2-related subcell by an ordered filling of transition metal atoms into trigonal prisms. This leads to different herringbone patterns for the networks of puckered and elongated hexagons of magnesium and indium atoms. CaTMg2...