CD1C是一种转膜蛋白,属于免疫球蛋白超家族的一员,它在人类免疫系统中发挥着重要的作用。 CD1C属于CD1家族,包括CD1A、CD1B、CD1C和CD1D四个亚型,它们在免疫系统中都扮演着不同的角色。与其他CD1家族成员不同的是,CD1C主要表达在树突状细胞(dendritic cells,DCs)和B细胞上。DCs是一类免疫细胞,能够与T细胞相互...
目的 探究EV71与CA16对恒河猴CD1c+DC的感染情况,与两者感染后Ⅰ型干扰素(typeⅠinterferon,IFN-Ⅰ)产生通路中及辅助性T细胞(T helper cells,Th)分化过程中相关基因的改变.方法 本文通过采用免疫荧光、qRT-PCR、噬斑实验、流式细胞术等方法比较了EV71与CA16感染恒河猴CD1c+DC在不同的时间点内IFN-Ⅰ的产生,病毒...
Abbreviations, CD numeration, and alternate names: DEC-205 (CD205), B220 (CD45R), PDCA-1 (plasmacytoid DC Ag-1; CD317; Bst2), Siglec H (Sialic acid-binding immunoglobulin-like lectin H), Langerin (CD207), CD141 (BDCA-3), CD1c (BDCA-1), and CD303 (BDCA-2). Dendritic cell ...
and IL-12 and instead produced high levels of the anti-inflammatory cytokine IL-10 and regulatory molecules IDO and soluble CD25. Moreover, E. coli-activated CD1c(+) DCs suppressed T-cell proliferation in an IL-10-dependent manner. Contrary to their mouse CD8(+) DC counterparts, human CD...
(a) Cells were double-stained with the indicated mAbs to assess the purity of DC suspensions. Numbers represent the percentage of cells in the respective quadrants. (b) Migrating LCs and DDCs were double-stained with anti-CD1c and the indicated mAbs. Flow cytometry profiles are from a ...
DC and monocyte fractions of human PBMCs were cultured in conditions that induce langerin in progenitor cells, including BMP7.19, 20, 21, 22, 23 This induced a rapid upregulation of langerin and CD1a dual expression by CD1c+ DCs, peaking within 3 days (Figure 1A-B). Langerin+ cells al...
Mutiny or scrutiny: NK cell modulation of DC function in HIV-1 infection. Trends Immunol. 2011;32(5):219–24. 29. Frleta D, Ochoa CE, Kramer HB, Khan SA, Stacey AR, Borrow P, et al. HIV-1 infection-induced apoptotic microparticles inhibit human DCs via CD44. J Clin Invest. 2012;...
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Notably, CD1c CD163 DC3s were expanded in the synovium and SF. Furthermore, we found that DC3s were primarily located within the ectopic lymphoid-like structure (ELLS) in close proximity to CD8 T cells. Finally, the level of TNF-α and IL12p70 in the SF correlated with the severity ...
In addition, interleukin-3 and type I interferons are stimuli specifically for DC maturation rather than cytokine secretion, whereas TNF-alpha is almost ineffective in inducing either function, suggesting a mechanism of T-cell-DC crosstalk and of rapid induction of antigen-presenting cell function ...