DCs是一类免疫细胞,能够与T细胞相互作用并启动免疫应答。B细胞是一类产生抗体的细胞,对于抗体介导的免疫防御起着重要作用。 CD1C基因编码的蛋白质称为CD1C分子,它位于细胞膜上,具有类似免疫球蛋白的结构。CD1C分子能够结合和呈递脂质抗原,与抗原特异性T细胞相互作用,从而激活免疫应答。 CD1C分子的主要功能是呈递非多肽...
Dendritic cells (DCs) comprise a heterogeneous group of antigen-presenting cells with many specialized functions, including essential constitutive roles in priming immune and autoimmune responses and in the maintenance of peripheral self-tolerance. At the interface of the innate and adaptive immune ...
Human blood myeloid DCs can be subdivided into CD1c (BDCA-1)(+) and CD141 (BDCA-3)(+) subsets that display unique gene expression profiles, suggesting specialized functions. CD1c(+) DCs express TLR4 while CD141(+) DCs do not, thus predicting that these two subsets have differential c...
目的:树突状细胞(DCs)是体内最强的抗原提呈细胞,在抗肿瘤、抗病毒感染免疫中起重要作用,近来有研究表明DCs通过分泌凋亡诱导蛋白参与了病毒性性肝炎的发病机理。本研究... 郑临,杨益大,吕国才 - 浙江省感染病、肝病学术年会 被引量: 0发表: 0年 银屑病患者骨髓CD34^+细胞HLA-C和PDCD1表达的研究 目的:研究HLA-...
Few data are available regarding the role of human skin dendritic cells (DCs) in driving T-cell responses. In this study we analyzed the relative capacity of Langerhans cells (LCs) and dermal CD14−CD1c+ DCs (DDCs) to trigger naive CD4+ T-cell proliferation and differentiation. DC ...
Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens The characterization of human dendritic cell (DC) subsets is essential for the design of new vaccines. We report the first detailed functional analysis of ... SL ...
Induction of a CD1a+ langerinhigh population was restricted to CD1c DCs treated with TGFβ, BMP7, or both (Figure 1D). No significant synergy was observed between TGFβ and BMP7, in contrast to recent results obtained with TGFβ and thymic stromal lymphopoietin (TSLP).24 No langerin ...
Human blood contains 2 populations of dendritic cells (DCs): plasmacytoid and myeloid (mDC). mDCs are subdivided into 3 subsets using the surface markers C... Diego,Piccioli,Simona,... - 《Blood》 被引量: 364发表: 2007年 CD1c(+) Myeloid Dendritic Cells in Myeloid Neoplasia We determined...
最后,我们对EV71与CA16感染恒河猴CD1c+树突状细胞(Dendritic cells,DCs)后的免疫反应进行了比较,结果发现,EV71感染CD1c+DC后I-IFN产生显著性下降,病毒载量、病毒... 胡雅洁 - 《北京协和医学院》 被引量: 0发表: 2017年 Comparative analysis of IFN-I production and Th differentiation related molecules subje...
We determined the normal level and phenotype of CD1c(+) myeloid dendritic cells (MDCs) in blood and bone marrow and evaluated the level of CD1c(+) MDCs in ... Howard,J.,Meyerson,... - 《Cytometry Part B Clinical Cytometry》 被引量: 1发表: 2016年 CD1c(+) myeloid dendritic cells ...