Positive FC detected in human PBMCs For other applications, we recommend the unconjugated version of this antibody, 65197-1-Ig 推荐稀释比 ApplicationDilution This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in...
CD19-targeting CAR T Cell Therapy in the Treatment of Relapsed or Refractory CD19 Positive B-cell Malignancies This is a single center, single arm, open-label phase 1 study to determine the safety and efficacy of autologous T cells expressing CD19 chimeric antigen receptors in adults with CD...
Immunogen Human chronic lymphocytic leukemia (CLL) cells 种属同源性预测 Host / Isotype Mouse / IgG2a Class Recombinant Type Antibody Full Name CD19 molecule Synonyms CD19 molecule, B-lymphocyte surface antigen B4, B-lymphocyte antigen CD19, B4, B lymphocyte antigen CD19 Calculated Molecular Weight...
3425 Poster Board III-313 MDX-1342 is a fully human monoclonal antibody (HuMAb) with enhanced antibody-dependent cellular cytotoxicity (ADCC) effector function, targeting CD19-membrane receptor which is highly expressed on malignant chronic lymphocytic leukemia (CLL) cells. An open-label, multi-...
相关研究结果发表在2020年2月6日的NEJM期刊上,论文标题为“Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors”。 在参与这项临床研究的11名患者中,8人(73%)对治疗作出反应,其中7人完全缓解,这意味着他们在中位随访13.8个月时不再显示疾病迹象。缓解后的治疗是对其中的5名有反应的...
Virtually all non T-ALL, B-CLL and B-cell lymphomas were found to be positive, myeloma cells were found to be negative. This product can be used for evaluation of residual disease in B-cell chronic lymphocytic leukemia patients and bone-marrow remission....
While the therapeutic outcomes for CD19-specific CAR-T cells have been impressive, the quality control during therapy manufacture remains an area in which more progress is required. Ourhigh-affinity CD19 proteinscan effectively detect the expression of anti-CD19 CAR on the surface of transduced T...
CD19is a double-edged sword, which functions as both positive and negative regulator in BCR signaling. • The biochemical basis of CD19 as BCR regulator is the recruitment of secondary signaling molecules like PI3K via its cytoplasmic tail, which may be inside or outside of lipid rafts, dep...
However, the persistence of CAR T-cells in these studies was generally limited to 3 months. An exception was long-lived CAR-T cells in two adult individuals with a different cancer—chronic lymphocytic leukemia (CLL)—in whom anti-CD19 CAR-T cells have persisted for almost a decade thus...
R萄icellsⅥ恤chareCD19 positive were allalyzedbyi11direct妇unological fluorescent assays or competitiVe iII】Inlunologicalfluorescent弱says wim FACS.Diabody or ds-Diabody werei11cubatedat 370CforvariouStimesinPBS containing0.2%(w,v)hum锄senmlalbumiIl(HSA)at ...