此外,近期研究表明,靶向CD19+B细胞的嵌合抗原受体(CAR)T细胞在难治性系统性红斑狼疮(SLE)、系统性硬化症和4例IIM(抗合成酶综合征伴间质性肺病)成人患者中具有极好的耐受性和疗效。 2024年6月,《Arthritis Rheumatol》杂志发表了一篇题为“...
希望今后的工作将提供急需的答案。 参考文献:Korol C, Rossi J, Sanz M, Bernasconi A. NK cells expressing the B cell antigen CD19: Expanding the phenotypical characterization and the potential consequences from misinterpretation of t...
今天给同学们分享一篇实验文章“Transcriptional signatures associated with persisting CD19 CAR-T cells in children with leukemia”,这篇文章发表在Nat Med期刊上,影响因子为82.9。 结果解读: 研究队列和实验概述 作者研究了15例高危或复发的CD19 B-ALL患者,这些患者接受了CD19 CAR-T细胞疗法,研究名称为CARPALL(N...
今天给同学们分享一篇实验文章“Transcriptional signatures associated with persisting CD19 CAR-T cells in children with leukemia”,这篇文章发表在Nat Med期刊上,影响因子为82.9。 结果解读: 研究队列和实验概述 作者研究了15例高危或复发的CD19 B-ALL患者,这些患者接受了CD19 CAR-T细胞疗法,研究名称为CARPALL(...
参考文献:Blumenberg V, Galina B, Baumann S, et al. Early quantification of anti-CD19 CAR T-cells by flow cytometry predicts response in R/R DLBCL [published online ahead of print, 2023 Sep 25]. Blood Adv. 2023;bloodadvances.2023010364. doi:10.1182/bloodadvances.2023010364 ...
产品名称:人CD19阳性B细胞 Human B cells 货号:LV-Bcell001 规格:5million/管 品系:中国人 供体数:单供体或者多供体 货期:1周 保存条件:液氨储存 运输条件:液氨运输 产品有效期:10年 质检项目:复苏数据(活率、活细胞数、污染物检测)、细胞FACS鉴定(Anti-CD8抗体)、悬浮效果等。
The purified human T cells were activated using ACRO Anti-CD3/CD28 Antibody-coupled Magnetic Beads (Cat. No. MBS-C001) and competitor’s beads respectively at a ratio of 1:1 beads-to-cells for 24 hours with RPMI1640 supplemented with 10% of FBS. Cells were fluorescently stained us ...
7参考文献[1] Dai H, Wu Z, Jia H, et al. Bispecific CAR-T cells targeting both CD19 and CD22 for therapy of adults with relapsed or refractory B cell acute lymphoblastic leukemia[J]. J Hematol Oncol, 2020, 13(1):53.[2] Turtle CJ, Hanafil A, Berger C, et al. CD19 CAR⁃T...
参考文献:Blumenberg V, Galina B, Baumann S, et al. Early quantification of anti-CD19 CAR T-cells by flow cytometry predicts response in R/R DLBCL [published online ahead of print, 2023 Sep 25]. Blood Adv. 2023;bloodadvances.2023010364. doi:10.1182/bloodadvances.2023010364 ...