浆细胞(plasma cell PC) 又称抗体分泌细胞(antibody secreting cell)。成熟B细胞接受抗原刺激后,在抗原提呈细胞和Th细胞的辅助下成为活化B细胞,进而分化为浆细胞,合成和分泌各类免疫球蛋白,同时获得了PC-1(plasma cell antigen-1)等浆细胞特异性标志,而mIg,MHCⅡ类抗原、CD19、CD20、CD21等标记消失。 CD19突变与...
参考文献: [1]Katharina H, Ann-Katrin C, Armin M R. Targeting B Cells and Plasma Cells in Autoimmune Diseases[J]. Frontiers in Immunology,2018,9:835. [2]Loriamini M, Cserti-Gazdewich C, Branch DR. Autoimmune Hemolytic Anemias: Classifications, Pathophysiology, Diagnoses and Management. Int...
CD19 is a molecule that is present on B cells from the earliest stages of development through the memory and plasma cell stage. Therefore, our goal was to characterize in detail the expression of CD19 on plasmablasts and plasma cells from human blood and tissues, and relate the phenotype ...
This protein is a reliable marker for pre-B cells but its expression diminishes during terminal B cell differentiation in antibody secreting plasma cells. The protein has two N-terminal extracellular Ig-like domains separated by a non-Ig-like domain, a hydrophobic transmembrane domain, and a ...
物种:人 宿主:仓鼠 抗体亚型:IgG 荧光染料:Purified 产品介绍 技术参数 相关产品 产品介绍 The HIB19 antibody reacts with CD19, an ~95 kDa type 1 transmembrane glycoprotein expressed on the surface of B cells throughout all stages of development, from early pre-B cells to plasma cells. Expression...
[17]. After this stage CD19 expression is one of the hallmarks of B cells. In the peripheral blood, it remains on the cell surface until differentiation into plasma cells. CD19 is a member of the Ig-superfamily. Its cytoplasmic tail serves as a specialized adaptor protein to recruit ...
the terminally differentiated plasma cells. Follicular dendritic cells also express CD19. Together CD21, CD81, MHC class II, and CD19 form a multimolecular complex that associates with the BCR. Signaling through CD19 induces tyrosine phosphorylation, calcium flux and proliferation of B cells. ...
CD19 is up-regulated at the step of B-lineage commitment during the differentiation of the hematopoietic stem cell, it remains on during subsequent stages of differentiation until finally down-regulated during terminal differentiation into plasma cells (PMID: 8528044). CD19 is involved in B cell ...
T cell and monocytic cell lines are negative and the antigen is lost on B cell maturation to plasma cells. The antigen is a type I integral membrane glycoprotein whose in vitro inhibition will influence B cell activation and proliferation. References 1. Rie, M.A. de, J. of Immunol. ...
plasma cells) and fllicular dendritic cells. CD19 is involved in B cell development, activation, and diferentiation. CD19 forms a complex with CD21 (CR2) and CD81 (TAPA-1), and functions as a BCR co-receptor. Product Details Reactivity Human, Chimpanzee, Rhesus Antibody Type Monoclonal Ho...