CD19(+)CD21(lo) B cells have been identified as an autoreactive-prone subset of B cells, although the downregulation of CD21 has been observed on a variety of B cell subsets in health and disease. This variation has led to confusion regarding the meaning and applicability of the loss or...
fit cells within a median vein-to-vein time of seven days, greater physician control and improved patient experience. The platform consists of an end-to-end xCellit® workflow management and monitoring software system, a decentralized, functiona...
CAR/CCR T cells demonstrate superior efficacy in xenograft mouse models compared with CAR T cells, superior long-term activity, and superior selectivity in in vitro assays with non-malignant CD19+ cells. In addition, immunocompetent mice show an intact CD80−CD19+ B cell population after CAR...
The starting concentration of the PBMC fractions depended on the percentage of T cells (50% ± 10%) and the chosen effector-to-target cell (E:T) ratio. Six aliquots, meaning six wells per dilution, of 100 μL of each PBMC dilution were plated in 96-well round-bottomed microtiter plates...