Our data suggest that CXCR5-CD19low B cells are precursors of plasmablasts, thus co-targeting this subset may have therapeutic value in SLE.doi:10.1101/2021.05.25.21257784F. SzelinskiA. StefanskiE. SchrezenmeierH. Rincon-ArevaloA. Wiedemann...
Compared with never cGVHD controls, patients with later cGVHD had significantly higher CD19+CD21low B cells (23.5% versus 15.2%, P = .004, Figure 1), CD4+ T cells (394 versus 127 × 106/L, P < .001), CD4+CD45RA+ naïve T cells (28.7% versus 16.3%, P < .001), and CD4+...
derived from patient myeloma cells. Meanwhile, CD19(+)CD38(low) xenografts were detected in human bone-bearing mice transplanted with CD19(+)CD38(low/-) B cells from 8 of 22 samples but were not clonally related to patient myeloma cells. Further fractionation and xenotransplantation of CD138...
IV期组的CD4^+CD25^+highCDl27^Low,CDl9^+,CDl9^+CD23^+表达量明显高于O-II期组;CD4^+CD25^+highCDl27^Low,CDl9^+CD23^+有明显的正相关性.结论B—CLL患者外周血中CD4^+CD25^+highCD127^Low的表达量增高,与CD19^+,CD19^+CD23^+的表达量增高明显相关,可能是B—CLL患者CD19^+CD23^+克隆性...
CD19+ B-cell counts were assessed by flow cytometry and multivariate statistical analysis adjusted for various potential predictors was performed. Results The rate of severe infection was 5.9/100 patient-years in RA patients and 24.9 in non-RA AID (P < 0.001). Low B-cell counts at the time...
These results suggest that CD19(-)CD45(low/-) fully differentiated plasma cells enrich for long-lived and tumor-initiating cells whereas B cells or plasmablasts do not. 展开 关键词: multiple myeloma myeloma-initiating cells xenotransplantation ...
ghCD127 的降低可能对EBV转化的“永生细胞”在体内的有效抑制起着主要的作用。 【关键词】EB病毒;传染性单核细胞增多症;CD19CD23;CD4CD25 ghCD127 StudyoftheinhibitionefectsofCD4 CD25 “ CD127 ontheimmortalizedcellsinchildren、vith infectiOUSmononucleosis ...
In addition, CD19 + B cells were generated from the graft-derived cells isolated from aorta–gonad–mesonephros (AGM) regions of the YS–YS chimeras; however, the frequency of the YS-derived B cell was low (1.0 ± 0.6%) when co-cultured with OP9 stromal cells. These results demonstrate...
目的探讨多发性骨髓瘤(MM)患者外周血CD4+CD25highCD127low/-调节性T(Tregs)细胞表达水平及临床意义。方法采用流式细胞术(FCM)检测30例MM患者和20例健康对照者外周静脉血CD4+CD25highCD127low/-Tregs细胞水平。结果 1 MM组CD4+CD25high CD127low/-Tregs细胞表达明显高于正常对照组(P<0.05)。2MM组不同国际分期系...
We first mounted a 10-μm-thick tonsil section obtained from a patient who underwent bilateral tonsillectomy on a metal frame LMD slide and performed four-color IF whole-slide imaging to detect B cells (CD19), T cells (CD3), epithelium (EP) (pan-CK), and DNA (DAPI) (Figures 4A and...