CD14++CD16− and CD14+CD16+ monocyte subsetsendothelial celladhesioncytokineBased on the difference in the CD14 and CD16 expression, two subsets of monocytes were identified in human and other mammalian blood. These subsets have different patterns of adhesion molecules and chemokine receptors that ...
CD14++CD16− monocytes, frequently described as classical monocytes, dominate in the peripheral circulation, compared to ‘non-classical’ CD14+CD16++. More recent work has identified an additional intermediate monocyte subset: CD14++CD16+ monocytes numerically represent the smallest monocyte population...
Gene Ontology (GO) enrichment analysis suggests diverse immunologic functions, linking CD14++CD16+ monocytes to Ag processing and presentation (eg, CD74, HLA-DR, IFI30, CTSB), to inflammation and monocyte activation (eg, TGFB1, AIF1, PTPN6), and to angiogenesis (eg, TIE2, CD105). In ...
Monocytes represent a heterogeneous population of cells subdivided according to the expression level of membrane antigens. A pro-inflammatory (intermediate/nonclassical) subpopulation of monocytes is defined by expression of CD16. CD163 seems to be chara
Different functions of monocyte subsets in familial hypercholesterolemia: potential function of CD14+CD16+ monocytes in detoxification of oxidized LDL We conclude that FH-CD14(+)CD16(+) monocytes have specialized functions in the uptake of oxLDL at activated endothelial cell surfaces, and we ... ...
The CD14brightCD16+ monocyte subset is expanded in rheumatoid arthritis and promotes expansion of the Th17 cell population Rossol M, Kraus S, Pierer M, Baerwald C, Wagner U: The CD14(bright) CD16+ monocyte subset is expanded in rheumatoid arthritis and promotes expansion of the Th17 cell popu...
AB0104Role of CD14+ and CD16+ Monocyte Subtypes in The Atherothrombosis Associated with Rheumatoid Arthritis: Epigenetic Mechanisms InvolvedBackgroundMonocytes play a key role in the pathogenesis of the cardiovascular disease (CVD). Three ... N Barbarroja,P Ruiz-Limon,C Perez-Sanchez,... - 《Ann...
The proportion of apoptotic cells in CD16 þ monocytes accumulated at a faster rate as the cells were cultured for up to 24 h. To determine the involvement of caspases in apoptosis, monocyte subsets were cultured for 24 h in the presence or absence of a pan-caspase inhibitor, zVAD-fmk....
The CD14 +CD16+ inflammatory monocyte subset displays increased mitochondrial activity and effector function during acute Plasmodium vivax malaria. PLoS Pathog 2014; 10:e1004393.Antonelli, L. R., Leoratti, F. M., Costa, P. A., Rocha, B. C., Diniz, S. Q., Tada, M. S., Pereira, ...
S2d). These collective findings signify an overall escalation in monocyte-related gene programs and impaired T cell-mediated anti-tumor functions in the peripheral immune cells of non-responders before ICB therapy. Further examination is required to unveil the contribution of monocytes to the limited ...