Read SW, Higgins J, Metcalf JA, Stevens RA, Rupert A, Nason MC, Lane HC, Sereti I: Decreased CD127 expression on T Cells in HIV-1-infected adults receiving antiretroviral therapy with or without intermittent IL-2 therapy. J Acquir Immune Defic Syndr 2006, 42:537-544....
结论CD127 在 CD8 阳性 T 细胞上表达的减少可能是导致艾滋病患者免疫功能缺陷的原因之一。【关键词】 艾滋病; CD127 ; CD8 ; 白介素 -7 受体中图分类号: R512.91文献标识码: BExamination of CD127 + T Cells in Peripheral Blood of Patients with AIDSJIANG Hong-kun , LIAO Qi-hong , LV Cheng( ...
10 lO 1O’ 1 0 4 C D8 兀代 图 l 艾滋病 患者 CD127+CD8 细胞 的表达情 况 F ig.1 T h e exp ressi0n 0f CD 127 CD 8 cells in patjents w itlI AII)S 2 .2 C D8+C D127 +细 胞在 艾滋 病 患者 和正 常人 中表达 的 比较 (表 1 ) 基 室鱼 U D ata.0 02 · 1 l...
即CD4+CD25+调节性T细胞(regulatory T cells, Treg cells)以来,随着人们对这群细胞的深入研究,认识到Tregs细胞的持续表达在机体免疫抑制反应和维持机体的免疫耐受状态起重要作用,这种Tregs细胞同时具有免疫无能性和免疫抑制性两大特点,约占外周血CD4+T细胞的5%～10%,该细胞数量减少或功能丧失...
and Miller SD., Cutting Edge: Anti-CD25 monoclonal antibody injection results in the functional inactivation, not depletion, of CD4+CD25+ T regulatory cells. J Immunol. 2006. 176:3301–3305 【12】.刘海红,黄宇锋,周军,等. 胃癌患者外周血CD4 + CD25 + 调节性T细胞的检测及其临床意义. 现代肿瘤学...
Tcellsinperipheralbloodmononuclearcells(PBMC)weredeterminedbyflowcytometrybeforeand3monthsafterHAART. Eightyhealthyindividualsservedascontrols.ResultsBeforeHAARTthecirculatingTreglevelsinHIVpatientsweresignificantly lowerthanthoseincontrols(8±2.20,33±10.03,P<0.01).TregwaspositivelycorrelatedwithCD4 + cellsinPBMCs(...
【2】Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic self tolerance maintained by activated T cells expressing IL-2 receptoralpha-chains (CD25). Breakdown of a single mechanismof selftolerancecauses various autoimmune diseases [J]. J Immunol,1995, 155 (3) : 1151-1164 【3】王会平,...
HIV-specific regulatory T cells are associated with higher CD4 cell counts in primary infection OBJECTIVE: Expansion of regulatory T (Treg) cells has been described in chronically HIV-infected individuals. We investigated whether HIV-suppressive Treg ... H Kared,JD Lelièvre,V Donkova-Petrini,......
Increased populations of regulatory T cells (Tregs) impair anti-tumor immunity. Recently, the transcription factor Foxp3 has been reported to play a key role in CD4(+)CD25(+) regulatory T cell function and represents a specific marker for these cells. However, Foxp3 is a nuclear protein and...
To investigated the changes in CD4+CD25+ CD127low regulatory T cells (Tregs) in the peripheral blood of patients with hepatocellular carcinoma ( HCC ) and ... 刘辉,朱争艳,王鹏,... - 《中国肿瘤临床》 被引量: 15发表: 2011年 原发性肝癌患者CD4+CD25+CD127low调节性T细胞的检测及意义 目的:...