的表达与CD4+T淋巴细胞计数、HIV RNA载量以及CD8+T淋巴细胞自发凋亡作相关性分析.组间比较采用Mann-Whitney U检验,Spearman评价组间相关性.结果 与健康对照组比较,HIV-1慢性感染组中CD8+T淋巴细胞CD127的表达显著下降,差异具有统计学意义(Z=-4.796,P<0.01).CD8+T淋巴细胞CD127的表达与患者CD4+T淋巴细胞计数呈...
10 lO 1O’ 1 0 4 C D8 兀代 图 l 艾滋病 患者 CD127+CD8 细胞 的表达情 况 F ig.1 T h e exp ressi0n 0f CD 127 CD 8 cells in patjents w itlI AII)S 2 .2 C D8+C D127 +细 胞在 艾滋 病 患者 和正 常人 中表达 的 比较 (表 1 ) 基 室鱼 U D ata.0 02 · 1 l...
in the skin. (A) Immunofluorescence staining (40x) of CD8 + T cells (green) from non-lesional (healthy, HC) or lesional atopic dermatitis skin. IL-7Ralpha + CD8 + T cells (upper panel) representing IL-7Ralpha high EM CD8 + T cells were stained with antibodies (Abs) to ...View ...
结论CD127 在 CD8 阳性 T 细胞上表达的减少可能是导致艾滋病患者免疫功能缺陷的原因之一。【关键词】 艾滋病; CD127 ; CD8 ; 白介素 -7 受体中图分类号: R512.91文献标识码: BExamination of CD127 + T Cells in Peripheral Blood of Patients with AIDSJIANG Hong-kun , LIAO Qi-hong , LV Cheng( ...
CD127是IL-7受体α链,T淋巴细胞对IL-7的特异性应答主要通过CD127的表达进行调控的。CD127在胸腺细胞向T淋巴细胞的发育过程、成熟T细胞内环境稳态的维持、病毒感染后T细胞的免疫应答及记忆性T细胞的分化及幸存等方面发挥重要的作用,在整个T淋巴细胞生命周期中仅有两个阶段缺乏CD127的表达:DP期T细胞及激活的T细胞。近...
The functional status of tumor-infiltrating CD8+T cells was also different between NAC and NAPC after neoadjuvant therapy. We compared the functional gene expression levels of CD8+T cells from NAC and NAPC, including co-stimulation molecules (ICOS, CD28, TNFRSF9), effector molecules (GZMK, GZM...
山西医科大学 硕士学位论文 特发性血小板减少性紫癜CD4+CD25+CD127-及CD3+CD4-CD8-调节 性T细胞变化情况及意义 姓名:*** 申请学位级别:硕士 专业:儿科血液 指导教师:**树 2011-03-17 山西医科大学硕士学位论文 II 特发性血小板减少性紫癜CD4 + CD25 + CD127 - 及CD3 + CD4 - CD8 - 调节性T 细胞变化...
CD127 is expressed on immature Bcells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes),peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be an usefulmarker for identifying memory and effector T cells. The ligation of IL-7 with ...
IL-7 R alpha (IL-7 receptor alpha; also CD127) is a 60-70 kDa member of the type I cytokine receptor family of molecules. It is expressed on resting naïve and memory CD8+ T cells, DN thymocytes, pre-B cells, Th1 CD4+ T cells, dendritic cells and monocytes. IL-7 R alpha hete...
Background Hepatitis C virus (HCV) causes persistent disease in ~85% of infected individuals, where the viral replication appears to be tightly controlled by HCV-specific CD8+ T cells. Accumulation of senescent T cells during infection results in considerable loss of functional HCV-specific immune ...