2月9日,来自奥地利国家大学的Ian Cockburn团队在Science Immunology发表了研究论文:Zeb2 drives the formation of CD11c atypical B cells which sustain germinal centers that control persistent infection。 首先,作者生成了人扁桃体B细胞的单细胞RNA测序数据集,并筛选出了可能促使ABC分化的高表达TF。为了验证这些转录因...
Newly discovered immune cells at the frontline of HIV infection Kirstie M. Bertram et al, Identification of HIV transmitting CD11c+ human epidermal dendritic cells, Nature Communications (2019). DOI: 10.1038/s41467-019-10697-w...
in vivo targeting of dendritic cells, Immunohistochemistry (frozen) Castro FV, Tutt AL, White AL, Teeling JL, James S, French RR, Glennie MJ. (2008). "CD11c provides an effective immunotarget for the generation of both CD4 and CD8 T cell responses" Eur J Immunol 38(8):2263-73....
in vivo targeting of dendritic cells, Immunohistochemistry (frozen) Castro FV, Tutt AL, White AL, Teeling JL, James S, French RR, Glennie MJ. (2008). "CD11c provides an effective immunotarget for the generation of both CD4 and CD8 T cell responses" Eur J Immunol 38(8):2263-73....
(生物谷Bioon.com) 原始出处: Kirstie M. Bertram, Rachel A. Botting, Heeva Baharlou, et al,.Identification of HIV transmitting CD11c+ human epidermal dendritic cells,Nature Communications(2019). DOI:10.1038/s41467-019-10697-w
CD11c+非典型B细胞(CD11c+ atypical B cells,ABC)又被称为年龄相关B细胞。ABC已知与慢性感染疾病和自免疫疾病有关,但我们对其在体液免疫应答中的功能了解较少。目前已知ABC的数量与自免疫疾病的病活性正相关,被认为是抗体分泌细胞的前体...
In protected animals, we found CD11c+ microglia forming contacts with astrocyte processes at the glia limitans and immune cells retained within perivascular spaces. Together, our study identified pathological hallmarks of chronic EAE progression and suggests that CD11c+ microglia may regulate immune cell...
After treatment with Cur, CD8 + CD11c + cells were decreased in the spleen and PPs, and the expression of major histocompatibility complex II, CD205, CD40, CD40L and intercellular adhesion molecule-1 was inhibited. IL-10, IFN-纬 and TGF-尾1 levels were increased compared with those in ...
CD11c^+细胞在炎症性皮肤病中的研究进展
Confocal immunofluorescent analysis of THP-1 cells, differentiated with TPA (12-O-Tetradecanoylphorbol-13-Acetate) #4174 (80 nM, 24 hr) followed by 24 hr without TPA, (left, positive) or HeLa cells (right, negative), using CD11c (3.9) Mouse mAb (green). Samples were mounted in ProLong...