2月9日,来自奥地利国家大学的Ian Cockburn团队在Science Immunology发表了研究论文:Zeb2 drives the formation of CD11c atypical B cells which sustain germinal centers that control persistent infection。 首先,作者生成了人扁桃体B细胞的单细胞RNA测序数据集,并筛选出了可能促使ABC分化的高表达TF。为了验证这些转录因...
Zeb2:CD11c+非典型B细胞形成的关键 CD11c+非典型B细胞(简称ABC,即CD11c+ atypical B cells),作为一类与年龄相关的特殊B细胞亚群,已被揭示与慢性感染及自身免疫疾病紧密相关。尽管其在这些病理状态下的作用逐渐显现,但关于CD11c+非典型B细胞在体液免疫应答中的确切功能仍显模糊,尤其是其作为抗体产生前体的角色尚未完全...
2月9日,来自奥地利国家大学的Ian Cockburn团队在Science Immunology发表了研究论文:Zeb2 drives the formation of CD11c+ atypical B cells which sustain germinal centers that control persistent infection。 首先,作者生成了人扁桃体B细胞的...
CD11c is widely known as a cell surface marker for dendritic cells, but we recently showed that it regulates neutrophil and T cell functions. Because we found that CD11c knockout (KO) mice had lower blood B cell counts, we characterized B cell profile in developmental stages. We found...
CD11a is a leukocyte marker that is expressed in B and T lymphocytes, macrophages, monocytes, neutrophils, basophils and eosinophils. CD11b is primarily expressed by monocytes, macrophages, natural killer cells, some B and T-cells, and granulocytes. CD11c is expressed in monocytes, macrophages, ...
背景资料 CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and hel...
in vivo targeting of dendritic cells Matsuo H, Yoshimoto N, Iijima M, Niimi T, Jung J, Jeong SY, Choi EK, Sewaki T, Arakawa T, Kuroda S. (2012). "Engineered hepatitis B virus surface antigen L protein particles for in vivo active targeting of splenic dendritic cells" Int J Nanomedicin...
CD11c expression has also been observed on activated NK cells, subsets of B cells, monocytes, granulocytes, and some B cell malignancies including hairy cell leukemia (4-7). Uotila, L.M. et al. (2013) J Biol Chem 288, 33494-9. Kohrgruber, N. et al. (1999) J Immunol 163, 3250-...
the 150 kDa integrin aX chain. CD11c non-covalently associates with β2 integrin to form the CD11c/CD18 heterodimer. This complex is expressed on monocytes, granulocytes, macrophages, NK, dendritic cells, and subset of T and B lymphocytes. CD11c/CD18 binds to CD54, iC3b and fibrinogen and...
N418抗体还被证明可以靶向DC的抗原(即通过CD11c),从低免疫原性抗原靶点快速产生抗体,用于抗肿瘤免疫调节和疫苗策略。N418单克隆抗体特异性结合小鼠树突状细胞表面,不结合腹腔巨噬细胞、B细胞或淋巴结细胞。N418抗体不会阻断树突细胞与T细胞的结合。 艾美捷InVivoMAb anti-mouse CD11c/InVivoMAb抗小鼠CD11c:...