CD117 is a stem cell marker and has been proposed as a CSC marker and prognostic indicator in human epithelial ovarian carcinoma [40], and cancer cells expressing CD117 are described as having characteristics of
Thus, this CD117 expressing cell was considered a prostate stem cell in adult tissue22. Thus, CD117 expression is associated with stemness in multiple cell types. CD117 is a member of the type III tyrosine kinase receptors which play a key role in cell signaling and are responsible for ...
CD117 is areceptor tyrosine kinasetype III. When this receptor binds to SCF it forms a dimer which activates signaling through second messengers. Signaling through CD117 plays a role in cell survival, proliferation, and differentiation. Mobilization ...
A TMB substrate solution is added which acts on the bound enzyme to induce a colored reaction product. The intensity of this colored product is directly proportional to the concentration of c-Kit present in the samples.This kit will recognize both endogenous and recombinant Human c-Kit. KIT ...
The mobilization of progenitor cells in response to α4-integrin blockade is markedly blunted in c-kitW/W-V mutant mice, which are defective in c-kit kinase activity but have normal levels of c-kit expression and SCF binding at the cell surface.131,139–141 Thus, the kinase activity of ...
On the other hand,CD11b was almost postive in all cases of CML-CP,but only 16.9% of the APL cases were found positive for this antigen. The CD117+CD11b-phenotype was present in 72.3% of APL cases while none of cases with CML�CCP with this phenotype. Almost all of the cases with...
The CD117+CD11b-phenotype was present in 72 10、.3% of APL cases while none of cases with CMLCP with this phenotype. Almost all of the cases with CML-CP had the phenotype of CD117-CD11b+. CD117-CD11b+ phenotype was detected in all patients recovering from APL with CD117+CD11b-...
On binding of KIT ligand at the extracellular domain, CD117 is activated and this initiates various downstream signaling pathways mediating cell survival, migra- tion, and proliferation depending on the cell type.1 Since the KIT gene was identified in the 1980s as a proto-oncogene, it has ...
Flow cytometry can be used to characterize single cells in an efficient and expedient manner [25], and can be used to describe DN cells which are present in limited amounts in the mouse thymus. Previously, a highly reproducible multi-color flow cytometry method was developed to increase thymocy...
In the field of hematopoietic stem cell transplantation, this goal is now becoming tangible as gene-editing technologies and novel conditioning agents are entering the clinical arena. Targeted immunologic depletion of hematopoietic stem cells (HSCs), which are at the very root of the hematopoietic ...