Remarkably, the CD1-sorted LCs showed no loss of their Birbeck granules and CD1a expression upon culturing and no spontaneous phenotypic and functional maturation into potent antigen-presenting cells (APCs). We conclude that human epidermal LCs obtained by the CD1c cell-sorting protocol are optimal...
CD1 activates T cells, but the function and size of the possible human T cell repertoires that recognize each of the CD1 antigen-presenting molecules remain unknown. Using an experimental system that bypasses major histocompatibility complex (MHC) restriction and the requirement for defined antigens,...
Positive staining (normal):pre B cells, B cell subset, T cells, macrophages, platelets, eosinophils, basophils, megakaryocytes, endothelial cells, brain, peripheral nerve, vascular smooth muscle, cardiac muscle, epithelia CD10 AkaCommonAcuteLymphoblasticLeukemiaAntigen (CALLA), neutral endopeptidase 24.11...
CD1属于免疫球蛋白超家族,分子结构与MHC I 类分子相似,主要分布在胸腺皮质细胞(CD4 +CD8 +)、树突状细胞、郎格汉斯细胞(Langerhans cells (CD1a >CD1b 、CD1e )、GM -CSF 单独激活的或与1L-4 共同激活的单核细胞(CDla 、CDlb 、CDle )、B 淋巴细胞(CDle )及肠道上皮细胞(CDld )0 CDl 限制T 淋巴...
CD(Cluster of differentiation)就是细胞膜表面的分化抗原群/分化抗原簇,应用聚类分析,可将来自不同实验室识别同一分化抗原的单克隆抗体归为一个CD,经由从1982年第1次国际上人类白细胞分化抗原会议(The Human Leucocyte Differentiation Antigen workshop,HLDA) 统一命名。迄今为至,人CD的序号已从CD1命名至CD350 (2009...
The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and ...
目前缺乏树突状细胞特异性标记物,可以使用多种标记物存在与否的组合来鉴定树突状细胞。树突状细胞对其它白细胞谱系的标志物(Lineage)呈阴性,例如CD3、CD14、CD19、CD20、CD56,不同的亚群可表达MHC Class II、CD1、CD8a、CD11b、CD11c等相关标志分子。 骨髓来源的抑制性细胞...
The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and ...
T cells autoreactive to the antigen-presenting molecule CD1a are common in human blood and skin, but the search for natural autoantigens has been confounded by background T cell responses to CD1 proteins and self lipids. After capturing CD1a-lipid complexes, we gently eluted ligands while pres...
CD 主要抗原表达(Main Antigen Expression)/其他名字/分子量(kDa) CD1a Cortical Thymocytes (stg), B cell subset, Dendritic cells, Langerhans cells 49,12 CD1b Cortical Thymocytes (mod), B cell subset, Dendritic cells, Langerhans cells 45,12 ...