CD1a Cortical Thymocytes (stg), B cell subset, Dendritic cells, Langerhans cells 49,12 CD1b Cortical Thymocytes (mod), B cell subset, Dendritic cells, Langerhans cells 45,12 CD1c Cortical Thymocytes (weak), B cell subset, Dendritic cells, Langerhans cells 43,12 CD2 T cells, NK cells LFA...
Gregory S, Zilber M, Charron D, Gelin C 2000 Human CD1a molecule expressed on monocytes plays an accessory role in the superantigen-induced activation of T lymphocytes. Hum Immunol 61:193–201 35. Kasinrerk W, Baumruker T, Majdic O, Knapp W, Stockinger H 1993 CD1 molecule expression ...
, 2010) recently reported studies focusing on the functional role of CD1a in lipid antigen presentation and T-cell activation in the skin, a fundamental question remains to be addressed as to how such high levels of CD1a expression are maintained in LCs. Certain factors and stimuli have been...
The CD1 family of proteins share some structural and functional characteristics with the MHC class I molecules; however, members of the CD1 family are not polymorphic. Similar to MHC class I, CD1a associates with the beta2-microglobulin and is thought to play a role in antigen presentation....
蛋白别名:CD1a; CD1A antigen, a polypeptide; cluster of differentiation 1 A; cortical thymocyte antigen CD1A; differentiation antigen CD1-alpha-3; epidermal dendritic cell marker CD1a; hTa1 thymocyte antigen; T-cell surface antigen T6/Leu-6; T-cell surface glycoprotein CD1a ...
Membrane expression early during T ontogeny, before TCR rearrangement, persists until terminal stages of T cell development Lower expression in memory T cells vs. naive T cells Positive staining (normal):mature peripheral T cells (85%), post-thymic T cells (majority), NK cells (majority), some...
CD45也被称为白细胞共同抗原(leukocyte common antigen, LCA),表达于除红细胞和血小板以外的所有造血细胞及其各分化亚群上,是常用的造血细胞标志物。 Tips:人CD45存在由编码胞外域的第4、5、6号外显子选择性剪切而产生的多种异构体,不同异构体的表达具有细胞类型的特异性,并取决于细胞活化和分化的状态,例如CD45...
Protein Function function:Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.,miscellaneous:During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid ...
expression declines after successful elimination of antigen. Additionally,Pdcd1mRNA is expressed in developing B lymphocytes during the pro-B-cell stage. PD-1’s structure includes a ITIM (immunoreceptor tyrosine-based inhibitory motif) suggesting that PD-1 negatively regulates TCR signals. PD-1 ...
The CD1 family of proteins share some structural and functional characteristics with the MHC class I molecules; however, members of the CD1 family are not polymorphic. Similar to MHC class I, CD1a associates with the beta2-microglobulin and is thought to play a role in antigen presentation. ...