In the literature one marker used to characterise CD4+ T-cell differentiation is CD45RC and we offer Mouse anti Rat CD45RC MCA53G in various formats. “CD4 T cells are phenotypically divided by the expression of high and low molecula...
In addition to its significant role in the chemotaxis of lymphocytes, human CCR7 has also been recognized as a marker for a distinct subset of memory T cells, the central memory (TCM) population. These cells are characterized by the expression of CCR7 and CD62L and reside within periphe...
To define reagents for delineating na茂ve versus activated T-cells and identify antigen-specific T-cells, we tested anti-human and anti-bovine T-cell specific cell surface marker reagents for cross-reactivity with canine peripheral blood mononuclear cells (PBMCs. Both CD4+ and CD8+ T-cells ...
In addition to its significant role in the chemotaxis of lymphocytes, human CCR7 has also been recognized as a marker for a distinct subset of memory T cells, the central memory (TCM) population. These cells are characterized by the expression of CCR7 and CD62L and reside within peripheral ...
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The expression of the CC chemokine receptor-7 (CCR7) by cancers, including melanoma, augments lymph node (LN) metastasis, but little is known about its role in lymphangiogenesis and anti-tumor immunity. We injected control B16 murine melanoma cells (pLNC
Owing to impaired homing of T cells and DCs, CCR7-deficient and plt/plt mice show delayed immune responses at sites where antigen is limited. CCR7 deficiency also impedes the steady-state migration of DCs from non-lymphoid organs, such as the intestine and lung, into the draining lymph nodes...
As chemokines, CCR7 and L-selectin can attract cytotoxic T lymphocytes, dendritic cells, and other cells with an attack ability to enter the tumor microenvironment, and also interact with tumor cells, further promoting lymph node metastasis. CD44v6, as a marker of tumor stem cells, is widely ...
The presence of microglial reactive phenotype after DOPAL treatment in vivo, together with a limited direct effect of DOPAL in microglial cells, suggests an indirect mechanism of activation of microglial cells by DOPAL injured neurons. CCL21 is a candidate neuroinflammatory marker in PD patients ...
3 These observations also suggested that ZAP-70 could have a biological role in CLL rather than only being a surrogate marker for genetically defined subgroups. This hypothesis was further corroborated by several groups describing an association of ZAP-70 expression with B-cell receptor (BCR)–...