Purpose of the study: While acute graft-versus-host-disease (GVHD) is a T cell-mediated disease caused by alloreactive donor T cells, we and others have highlighted that patients who received higher proportion of donor CD4+ nave and central memory T cells expressing the chemokine receptor 7 (...
In previous studies, we and others observed in patients undergoing HLA-matched hematopoietic cell transplantation that high proportion of donor-derived CD4/CCR7T cells were associated with an increased risk of acute GVHD without any interference in relapse incidence. We investigated the impact of donor...
CCR7 is a critical element for immune cell trafficking and recirculation, that is, lymph node homing, under homeostatic conditions; blocking CCR7(+) central memory cells from egress of lymph nodes is a therapeutic approach in MS. To define the effect of CD4(+) T cell-specific constitutive ...
ccr7是什么细胞的标志初始T细胞(naive T cell，Tn)，也称作未致敏T细胞，在胸腺中发育成熟与迁移至外周...
初始T细胞(naive T cell,Tn),也称作未致敏T细胞,在胸腺中发育成熟迁移至外周淋巴组织中(如脾脏、淋巴结)。其未接触抗原刺激前处于相对静止状态,在胸腺中发育的一类带有CD4、TCR/CD3、CD28、CD62L、CCR7等表面分化抗原的T细胞。其通过抗360问答原刺激或树突状细胞(Dendritic cell,DC)的做若约际万额机当促递呈作用...
初始T细胞(naive T cell,Tn),也称作未致敏T细胞,在胸腺中发育成熟与迁移至外周淋巴组360问答织中(如脾脏、淋巴结)。其未接触抗原刺激前处于相对静止状态,在胸腺探为亮构首必做音选含支中发育的一类带有CD4、TCR/CD3、CD28、CD62L、CCR7等表面分化抗原的T细胞。其通过抗原刺呢市测否层激或树突状细胞(Dendritic ...
ccr7是什么细胞的标志初始T细胞(naive T cell，Tn)，也称作未致敏T细胞，在胸腺中发育成熟迁移至外周淋巴...
Thus, the central memory CD4 T cells that traffic though lymph nodes, which are often defined by their expression of CCR7, do not appear to gain any competitive homing advantage by expressing this receptor. Furthermore, in contrast to cutaneous dendritic cell populations, we found that CCR7 ...
Purpose The profile of central (=T-CM) and effector (=T-EM) memory CD4(+) T cell subsets and the possible role as surrogate markers of protection is studied in the volunteers with history of cutaneous leishmaniasis (HCL).Methods Profile of T cell subsets based on CCR7/CD45RA expressions...
16.非专利文献8:lanzavecchia,a.and sallusto,f.(2005).understanding the generation and function of memory t cell subsets.curr opin immunol 17,326-332. 17.非专利文献9:gattinoni,l.(2014).memory t cells officially join the stem cell club.immunity 41,7-9. ...