CCL17又称胸腺活化调节趋化因子（TARC），主要在胸腺中表达，也表达于其他组织如肺、结肠、小肠等。该趋化因子与CCR4特异性结合，诱导T细胞的趋化作用。CCL22又称巨噬细胞源趋化因子（MDC），主要由树突状细胞和巨噬细胞分泌产生，通过与细胞表面受体CCR4结合，对T淋巴细胞、B淋巴细胞和树突状细胞的分化、发育、增殖...
这一发现发表在《Journal for Immuno Therapy of Cancer》上的一篇题为“Anti-CCR4 treatment depletes regulatory T cells and leads to clinical activity in a canine model of advanced prostate cancer”的论文中。 Maeda说:“我们认为狗前列腺癌和人类前列腺癌是相似的。因此,我们假设狗前列腺癌和人类前列腺癌之...
[12] Olkhanud, Purevdorj B.,et al. "Breast cancer lung metastasis requires expression of chemokine receptor CCR4 and regulatory T cells." Cancer research 69.14 (2009): 5996-6004. [13] Kurose, Koji,et al. "Increase in activated Treg in TIL in lung cancer and in vitro depletion of Treg...
CCR4-bearing T cells participateKim, Soon HCleary, Mary MFox, Howard SChantry, DavidSarvetnick, Nora
CCR4 is a G protein-linked seven transmembrane domain chemokine receptor that binds the chemokines CCL17/TARC and CCL22/MDC. Current evidence suggests that CCR4 expression is associated with Th-2 type T cells and with platelets. CCR4 expression has also been reported in mature dendritic cells....
2021年9月12日,中国科学院生物物理研究所杨鹏远课题组与解放军总医院第五医学中心王福生课题组合作在Journal of Hepatology杂志发表题为Intratumoral stem-like CCR4+regulatory T cells orchestrate the immunosuppressive microenvironment in HCC associated...
cc趋化因子受体4(ccr4)是cc趋化因子ccl17和ccl22的同源受体,并在功能上不同的t细胞亚组(包括t辅助2型细胞(th2))和大多数调节性t细胞(treg)上表达。越来越多的证据表明,ccl17/22分泌促进恶性实体如结肠直肠癌、卵巢癌、霍奇金淋巴瘤(hodgkin'slymphoma)和胶质母细胞瘤肿瘤浸润性treg数量增加。肿瘤中treg水平增加...
2021年9月12日,中国科学院生物物理研究所杨鹏远课题组与解放军总医院第五医学中心王福生课题组合作在《Journal of Hepatology》杂志发表题为"Intratumoral stem-like CCR4+regulatory T cells orchestrate the immunosuppressive microenvironment in HCC associated with hepatitis B"的研究论文,阐述了瘤内CCR4介导调节性T细胞...
CCR4 is expressed in cutaneous regulatory T cells (Tregs). These cells arecrucial for the induction and maintenance of self-tolerance and are present in peripheraltissues such as skin and gut under normal, noninflamed conditions (4).In addition, recruitmentof Foxp3+ T regulatory cells mediating ...
cc趋化因子受体4(ccr4)是cc趋化因子ccl17和ccl22的关联受体(cognatereceptor),并在功能上不同的t细胞亚型上表达,所述t细胞亚型包括t辅助2型细胞(th2)和大多数的调节t细胞(treg)(iellem等,2001;和imai等,1999)。越来越多的证据表明ccl17/22分泌促进由例如结肠直肠、卵巢、霍奇金淋巴瘤和成胶质细胞瘤等恶性实体...