这一发现发表在《Journal for Immuno Therapy of Cancer》上的一篇题为“Anti-CCR4 treatment depletes regulatory T cells and leads to clinical activity in a canine model of advanced prostate cancer”的论文中。 Maeda说:“我们认为狗前列腺癌和人类前列腺癌是相似的。因此,我们假设狗前列腺癌和人类前列腺癌之...
Both TSLP and IL-16 induced migratory responses of CCR4+TSLPR+CD4+CCR7CD31+ cells, characteristic of malignant T cells in the skin. Co-stimulation also resulted in significant proliferative responses. We conclude that TSLP and IL-16, expressed at early stages of disease, function to recruit ...
CCL17又称胸腺活化调节趋化因子（TARC），主要在胸腺中表达，也表达于其他组织如肺、结肠、小肠等。该趋化因子与CCR4特异性结合，诱导T细胞的趋化作用。CCL22又称巨噬细胞源趋化因子（MDC），主要由树突状细胞和巨噬细胞分泌产生，通过与细胞表面受体CCR4结合，对T淋巴细胞、B淋巴细胞和树突状细胞的分化、发育、增殖...
[12] Olkhanud, Purevdorj B.,et al. "Breast cancer lung metastasis requires expression of chemokine receptor CCR4 and regulatory T cells." Cancer research 69.14 (2009): 5996-6004. [13] Kurose, Koji,et al. "Increase in activated Treg in TIL in lung cancer and in vitro depletion of Treg...
使用人源化可变重和(Vh)和κ轻(VI)链部分靶向CCR4的CAR可以衍生自与莫格利珠单抗(mogamulizumab)不同的抗CCR4抗体(Perera LP,Zhang M,Nakagawa M,et al.Chimeric antigen receptor modified T cells that target chemokine receptor CCR4 as a therapeutic modality for T cell malignancies.Am.J.Hematol.2017;92...
2021年9月12日,中国科学院生物物理研究所杨鹏远课题组与解放军总医院第五医学中心王福生课题组合作在《Journal of Hepatology》杂志发表题为"Intratumoral stem-like CCR4+regulatory T cells orchestrate the immunosuppressive microenvironment in HCC associated with hepatitis B"的研究论文,阐述了瘤内CCR4介导调节性T细胞...
CCR4mediated chemotaxis of regulatory T cells suppress the activation of T cells and NK cells via TGF-βpathway in human non-small cell lung cancer. Liu W,Wei X,Li L,et al. Biochemical and Biophysical Research Communications . 2017Liu W, Wei X, Li L, Wu X, Yan J, Yang H, Song F...
摘要: CD4(+) regulatory T cells (Tregs) are a distinct population of T cells involved in maintaining peripheral tolerance to self-antigens. Several studies have shown increased frequency... 查看全部>>关键词:Tregs Cytomegalovirus Elderly Mortality ...
Cutaneous T cell lymphoma (CTCL) is a clonal epidermotropic malignancy of memory T cells primarily involving the skin. However, the mechanisms governing migration of CTCL cells have not been fully clarified. It has been shown that certain chemokine receptors are upregulated in CTCL cells, but ...
2021年9月12日,中国科学院生物物理研究所杨鹏远课题组与解放军总医院第五医学中心王福生课题组合作在Journal of Hepatology杂志发表题为Intratumoral stem-like CCR4+regulatory T cells orchestrate the immunosuppressive microenvironment in HCC associated...