CCL17又称胸腺活化调节趋化因子（TARC），主要在胸腺中表达，也表达于其他组织如肺、结肠、小肠等。该趋化因子与CCR4特异性结合，诱导T细胞的趋化作用。CCL22又称巨噬细胞源趋化因子（MDC），主要由树突状细胞和巨噬细胞分泌产生，通过与细胞表面受体CCR4结合，对T淋巴细胞、B淋巴细胞和树突状细胞的分化、发育、增殖...
Squamous cell carcinoma of the lungRegulatory T cellCCR4Foxp3To clarify the prognostic impact of tumor-infiltrating effector regulatory T cells (eTregs) in non-small cell lung cancer (NSCLC), eTregs were evaluated by immunohistochemical detection of CCR4 and Foxp3 in 108 consecutive surgical NSCLC...
2021年9月12日,中国科学院生物物理研究所杨鹏远课题组与解放军总医院第五医学中心王福生课题组合作在Journal of Hepatology杂志发表题为Intratumoral stem-like CCR4+regulatory T cells orchestrate the immunosuppressive microenvironment in HCC associated...
34.mackensena,meidenbauern,vogls,laumerm,bergerj,andreesenr.phaseistudyofadoptivet-celltherapyusingantigen-specificcd8+tcellsforthetreatmentofpatientswithmetastaticmelanoma.journalofclinicaloncology:officialjournaloftheamericansocietyofclinicaloncology2006;24(31):5060-9. 35.morsema,hobeikaac,osadat,serrad,nie...
cc趋化因子受体4(ccr4)是cc趋化因子ccl17和ccl22的关联受体(cognatereceptor),并在功能上不同的t细胞亚型上表达,所述t细胞亚型包括t辅助2型细胞(th2)和大多数的调节t细胞(treg)(iellem等,2001;和imai等,1999)。越来越多的证据表明ccl17/22分泌促进由例如结肠直肠、卵巢、霍奇金淋巴瘤和成胶质细胞瘤等恶性实体...
1PCT/US2020/034389CCR4 TARGETED CHIMERIC ANTIGEN RECEPTOR MODIFIED T CELLS FOR TREATMENT OF CCR4 POSITIVE MALIGNANCIES PCT未进入指定国(指定期满) 联系方式在线咨询 客服电话:400-928-2212 工作时间:工作日 9:00-20:00 客服邮箱:kefu@qcc.com 商务合作:bd@qcc.com ...
2021年9月12日,中国科学院生物物理研究所杨鹏远课题组与解放军总医院第五医学中心王福生课题组合作在《Journal of Hepatology》杂志发表题为"Intratumoral stem-like CCR4+regulatory T cells orchestrate the immunosuppressive microenvironment in HCC associated with hepatitis B"的研究论文,阐述了瘤内CCR4介导调节性T细胞...
CC族趋化因子受体4(CC chemokine receptor 4,CCR4)是肿瘤转移中常见的趋化因子受体[1]。CCL22被称为巨噬细胞来源的趋化因子(macrophage-derived chemokine,MDC),CCL17也被称为胸腺和活化调节的趋化因子(thymus and activation-regulated ...
CCR4 is expressed in cutaneous regulatory T cells (Tregs). These cells arecrucial for the induction and maintenance of self-tolerance and are present in peripheraltissues such as skin and gut under normal, noninflamed conditions (4).In addition, recruitmentof Foxp3+ T regulatory cells mediating ...
The binding of a T cell to an Ag-laden dendritic cell (DC) is a critical step of the acquired immune response. Herein, we address whether a DC-produced chemokine can induce the arrest of T cells on DC under dynamic flow conditions. Ag-primed T cells and a T cell line were observed ...