These findings suggest that CCR2 on CD14(+)CD16(+) monocytes may be a peripheral blood biomarker of HAND, indicative of increased HIV infected CD14(+)CD16(+) monocyte entry into the CNS that possibly increases the macrophage viral reservoir and contributes to HAND.Veenstra, Mike...
摘要: Monocytes have been categorized in three main subpopulations based on CD14 and CD16 surface expression. Classical monocytes express the CD14(++)CD16(-)CCR2(+) phenotype and migrate to inflammatory...关键词: macrophages AIDS DOI: 10.1189/jlb.1111579 ...
Data are presented on a special group of cytokine proteins called chemokines, whose major and most important function is to stimulate the migration of leukocytes and other cells, thus they are involved in all protective, as well as destructive immune and inflammatory reactions. Chemokines mediate hap...
numerous inflammatory cells accumulate in the colonic lamina propria31. Flow cytometry was used to detect inflammatory cells infiltrated into the lamina propria, and inflammatory cells (CD45+) accumulated on a large scale in the DSS-induced colitis with mIgG-treated group compared with the normal gr...
There was no demonstrable impact on log-transformed baseline monocyte CD14+16+ subpopulations, baseline C-reactive protein, or baseline MCP-1 on log-change UACR at week 12, due to the lack of a strong treatment effect of PF-04634817 at that time point. A marked and sustained increase in se...
(CD14++CD16-CCR2+ [classical, Mon 1], CD14++CD16+CCR2+ [intermediate, Mon 2] and CD14+CD16++CCR2- [non-classical, Mon 3]) and their aggregates with platelets (monocyte-platelet aggregates, MPAs) were quantified by flow cytometry in 71 CAD patients (subdivided into a group with ...
The surface expressions of CCR2, CX3CR1, CD64 and CD62L were measured in the three monocyte subsets (classical, non-classical and intermediate) by flow cytometry.ResultsThe percentages of CCR2 and CD62L on CD14+CD16 classical monocytes were significantly lower in ALS patients than in HC (...
Besides routine clinic laboratory evaluation, to determine subtypes and activation status of monocytes, flow cytometry analyzes were performed on peripheral blood. In multi- colored analyze CD14-FITC, CD16-PE and CCR2-PerCP were used. Monocyte percentages and monocyte subtype were determined. CCR2 ...
Antibodies to ALCAM and JAM-A inhibited the transmigration of both HIV infected and uninfected CD14+CD16+ monocytes across the BBB, demonstrating their importance in facilitating monocyte transmigration and entry into the brain parenchyma. Targeting CCR2, JAM-A, and ALCAM present on CD14+CD16+ ...