These findings suggest that CCR2 on CD14(+)CD16(+) monocytes may be a peripheral blood biomarker of HAND, indicative of increased HIV infected CD14(+)CD16(+) monocyte entry into the CNS that possibly increases the macrophage viral reservoir and contributes to HAND.Veenstra, Mike...
(B) Quantification of CD116 expression on the monocyte subsets of P1–P5 and local (LC, n = 3) and travel (TC, n = 1) controls. (C) FACS plots depicting the amounts of pSTAT5 induced by GM-CSF (20 ng/mL) or IL-3 (100 ng/mL) in CD14+ monocytes from healthy controls, P1...
摘要: Monocytes have been categorized in three main subpopulations based on CD14 and CD16 surface expression. Classical monocytes express the CD14(++)CD16(-)CCR2(+) phenotype and migrate to inflammatory...关键词: macrophages AIDS DOI: 10.1189/jlb.1111579 ...
There was no demonstrable impact on log-transformed baseline monocyte CD14+16+ subpopulations, baseline C-reactive protein, or baseline MCP-1 on log-change UACR at week 12, due to the lack of a strong treatment effect of PF-04634817 at that time point. A marked and sustained increase in se...
Ly6ChiCCR2+CD62L+CX3CR1midmouse monocyte subset and the human counterpart CD14+cells that are generated from bone marrow and whose precursors are monocyte-dendritic cell progenitors and common monocyte progenitors49. CCR2 has been proved to be essential for the release of this subset from the ...
ArticleCASPubMedGoogle Scholar Tapp, L.D., Shantsila, E., Wrigley, B.J., et al., The CD14++CD16+monocyte subset and monocyte-platelet interactions in patients with ST-elevation myocardial infraction, Author information Authors and Affiliations ...
(CD14++CD16-CCR2+ [classical, Mon 1], CD14++CD16+CCR2+ [intermediate, Mon 2] and CD14+CD16++CCR2- [non-classical, Mon 3]) and their aggregates with platelets (monocyte-platelet aggregates, MPAs) were quantified by flow cytometry in 71 CAD patients (subdivided into a group with ...
However, the roles of each monocyte subset, namely CD14+CD16 classical monocytes, CD14dimCD16+ non-classical monocytes and CD14+CD16+ intermediate monocytes, in ALS remain unknown. We aimed to clarify the alterations in the monocyte subset proportions and the surface marker expressions on each ...
Functional Contribution of Elevated Circulating and Hepatic Non-Classical CD14+CD16+ Monocytes to Inflammation and Human Liver Fibrosis Monocyte-derived macrophages critically perpetuate inflammatory responses after liver injury as a prerequisite for organ fibrosis. Experimental murine mode... HW Zimmermann,S...
Besides routine clinic laboratory evaluation, to determine subtypes and activation status of monocytes, flow cytometry analyzes were performed on peripheral blood. In multi- colored analyze CD14-FITC, CD16-PE and CCR2-PerCP were used. Monocyte percentages and monocyte subtype were determined. CCR2 ...