The recombinant human CCL11 protein increased the proportion of CD4 +CD25 +Foxp3 + Treg cells, the expression of CCR3 and Foxp3, and the release of IL-2 and TGF-β1 in non-tumor-associated CD4 + T cells via the STAT5 signaling pathway. The results of the present study may aid in ...
Interleukin-4 in the presence of TNF-α or IL-1β induced mild secretion (20 –50 pg/ml) of CCL-11 and 26 by these cells. Our results show that the expression of CCR-3 ligands by HRPE and HCHF cells was upregulated by inflammatory cytokines. These data demonstrate that inflammatory ...
浙江理工大学硕士学位论文携带趋化因子CCL5的Ad5/11嵌合型增殖腺病毒对肝癌杀伤作用的研究姓名:***学位级别:硕士专业:生物化学与分子生物学指导教师:**军20090319.docin.com浙江理工大学硕士学位论文携带趋化因子CCL5的Ad5/11嵌合型增殖腺病毒对肝癌杀伤作用的研究摘要增殖型腺病毒又称条件复制型腺病毒或溶瘤病毒,可...
They regulate the recruitment and activation of eosinophils, monocytes, T cells, basophils and mast cells through CCR3, CCR5 and CCR2 receptors. We have previously shown that Eotaxin/CCL11 induces proliferation of airway fibroblasts and this effect is partially mediated by CCR3. We hypothesized ...
Thus, CXCL4 appears to play an auxiliary role in CCL5-mediated CCR1 activation, a function that might be of crucial importance for the in vivo activity of CCL5. This notion is also supported by recent studies that implemented MKEY in mouse models of inflammatory disease. For example, MKEY ...
Rantes已知可结合4种跨膜G-蛋白偶合的受体:CCR1,CCR3,CCR4 和 CCR5。CCR5是hiv-1 R5受体变种的辅助受体(co-receptor)。体外实验已证实Rantes等可以完全抑制hiv-1和CCR5的反应。小鼠的Rantes前体是一种91个氨基酸的高碱性蛋白质,切除23个氨基酸的疏水性引导肽后,形成68个氨基酸的成熟肽。
RANTES能够与CCR1、CCR3、CCR4、CCR5等4种G蛋白偶联受体作用。RANTES能够激活多种信号通路,例如在T细胞中,RANTES能够刺激细胞内Ca2+浓度升高,激活FAK、PKA、PI3K等多种蛋白激酶和JAK/STAT信号通路。巨细胞病毒US28与CC趋化因子受体具有高度同源性,也能够与RANTES结合。在不同细胞环境下,跨膜的US28能够与RANTES结合激活...
此外,这种融合疫苗还在肿瘤中诱导了一个由先天免疫细胞和特异性免疫细胞组成的肿瘤致死性微环境。机制研究表明,CCR3+细胞参与了这些免疫增强作用。这一发现为深入了解核酸疫苗在癌症治疗中的作用机制提供了新的线索。 值得一提的是,研究者们还尝试了将CCL11用于mRNA疫苗设计,以探索其在不同类型核酸疫苗中的应用潜力。
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10.1158/1078-0432.CCR-06-0074. Article CAS PubMed Google Scholar Soria G, Ben-Baruch A: Concomitant expression of the chemokines RANTES and MCP-1 in human breast cancer: A basis for tumor-promoting interactions. Cytokine. 2008, 44: 191-200. 10.1016/j.cyto.2008.08.002. Article CAS Pub...