CCL3/CCR1 axisCD14(+)CD16(−)knee osteoarthritismonocytesObjectives: Monocyte-derived macrophages, as the predominant immune cell type that is increased in inflamed synovium, play a vital role during knee osteoarthritis (KOA) progression. However, the mechanisms underlying the recruitment of ...
We demonstrate a novel pro-inflammatory role for CCL3/MIP-1α since CCL3/MIP-1α deficiency significantly attenuated hepatic injury, both biochemically and histologically. Moreover, the recruitment of CCR1-expressing CD4+ T cells to the liver after Con A treatment was strikingly attenuated ...
Whereas CCR1 re-expression after stimulation with CCL3 reached prestimulation levels (120 min: 81.3% relative CCR1 surface expression) CCL5 induced a prolonged CCR1 internalization (120 min: 15.7%). Conclusions: This study demonstrates a distinct pattern of CCR1 internalization and re-expression ...
aTwelve transcripts were higher in IN animals, including TAFA2 (distantly related to CCL3), CCR1 and CXCR4. 十二本抄本是高在动物,包括TAFA2 (遥远地与CCL3有关), CCR1和CXCR4中。[translate]
CCL3/CCR1 axisCCL2/CCR2 axisCD14(+)CD16(-)MonocytesKnee osteoarthritisObjectives: Monocyte-derived macrophages, as the predominant immune cell type that is increased in inflamed synovium, play a vital role during knee osteoarthritis (KOA) progression. However, the mechanisms underlying the ...
CCL3/CCR1放射性肺损伤肺功能目的 探讨乌司他丁对于食管鳞状细胞癌患者放射性肺损伤的保护作用以及可能的分子机制.方法 选取2018年1月至2019年1月在我院进行根治性调强放疗或术后调强放疗的食管鳞状细胞癌患者60例,按照1:1的比例随机分为对照组和试验组.两组均接受三维适形调强放疗.试验组在放疗前,后连续3d注射...
Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression. Int. J. Cancer 118:1869-1876.Yang X,Lu P,Fujii C,Nakamoto Y,Gao JL,Kaneko S,Murphy PM,Mukaida N.Essential contribution of a chemokine, CCL3, and its recep tor, CCR1, to ...
CCR1 receptor antagonists; inhibitors of MIP-1 alpha (CCL3) binding to its receptor CCR1 found on inflammatory and immunomodulatory cells; macrophage inflammatory protein (MIP)doi:US6974817 B2A compound of the formula or the pharmaceutically acceptable salt thereof; wherein X, Y, a, b, c, d...
CCL3/MIP-1alpha is pro-inflammatory in murine T cell-mediated hepatitis by recruiting CCR1-expressing CD4(+) T cells to the liver. Eur J Immunol. 2004;34:2907---18.Ajuebor, M. N., Hogaboam, C. M., Le, T., Proudfoot, A. E. and Swain, M. G. (2004)....
PS2-059. Essential roles of CCL3-CCR1 axis in the pathogenesis of antigen-induced arthritisWe report a case of fatal intoxication caused by the ingestion of an organophosphate pesticide, methidathion (DMTP). An 80-year-old male was found dead in his bed. Forensic autopsy revealed no ...