目的评价瑞芬太尼诱发切口痛大鼠痛觉过敏时脊髓趋化因子配体3(CCL3)和趋化因子CC亚族受体5(CCR5)表达水平的变化。 方法雄性SD大鼠32只,体重240～260 g,2～3月龄,采用随机数字表法,分为4组( n=8):对照组(C组)、切口痛组(I组)、瑞芬太尼组(R组)和瑞芬太尼+切口痛组(R+I组)。于切口痛模型制备的同时静脉...
Moreover, infiltrating macrophages express C-C chemokine receptor 5 (CCR5, a specific receptor for CCL3) and MMP-9. Both Ccl3/ mice and Ccr5/ but not Ccr1/ mice exhibit exaggerated CaCl2-inducced AAA with augmented macrophage infiltration and MMP-9 expression. Similar observations are also ...
目的:目前证据表明免疫应答在神经损伤中有重要作用,脊髓胶质细胞,IL-4(白介素-4),CCL3及其受体CCR5,p38MAPK信号通路都参与了神经炎症反应和神经病理性疼痛.因此,本研究旨在探讨IL-4/CCL3/CCR5在神经病理性疼痛中的作用,...
CCL3 (MIP-1α), a prototype of CC chemokines, is a potent chemoattractant toward human neutrophils pre-treated with GM-CSF for 15 min. GM-CSF-treated neutrophils migrate also to the selective CCR5 agonist CCL4 ?MIP-1β). CCL3- and CCL4-triggered migration of GM-CSF-primed neutrophils was...
Sasaki S, Baba T, Shinagawa K, Matsushima K, Mukaida N. Crucial involvement of the CCL3-CCR5 axis-mediated fibroblast accumulation in colitis-associated carcinogenesis in mice. Int J Cancer. 2014; 135:1297-1306.S. Sasaki, T. Baba, K. Shinagawa, K. Matsushima, N. Mukaida, Crucial ...
These data indicate that T-cell migration into human atherosclerotic plaques may predominantly occur via CCR5-CCL3 and CX3CR1-CX3CL1 interactions.doi:10.1002/eji.202049004Alexey KomissarovDaria PotashnikovaMichael L. FreemanVladimir Gontarenko
Mukaida, Crucial involvement of the CCL3-CCR5 axis-mediated fibroblast accumulation in colitis-associated carcino- genesis in mice, Int. J. Cancer 135 (2014) 1297-1306.S. Sasaki, T. Baba, K. Shinagawa, K. Matsushima, N. Mukaida, Crucial involvement of the CCL3-CCR5 axis-mediated ...
CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms. Nat. Immunol. 8 1324–1336. 10.1038/ni1521 [ Cross Ref ]Dolan MJ, Kulkarni H, Camargo JF, He W, Smith A, Anaya JM, Miura T, Hecht FM, Mamtani M, Pereyra F, ...
受体,CCR5脊髓目的评价瑞芬太尼诱发切口痛大鼠痛觉过敏时脊髓趋化因子配体3(CCL3)和趋化因子CC亚族受体5(CCR5)表达水平的变化.方法雄性sD大鼠32只,体重240～260g,2～3月龄,采用随机数字表法,分为4组(n=8):对照组(c组),切口痛组(I组),瑞芬太尼组(R组)和瑞芬太尼+切121痛组(R+I组).于切口痛模型制备的...
In this study, we investigated the role of interleukin-4 and the chemokine/chemokine receptor pair CCL3/CCR5 in a mouse model of chronic constriction injury (CCI)-induced neuropathic pain. Neuropathic pain was induced by surgical ligation of the sciatic nerve and assessed by measuring thermal ...