A CCL3 receptor, CC chemokine receptor 5 (CCR5) was expressed in the ESCC cell lines. Treating the ESCC cell lines with recombinant human (rh)CCL3 induced the phosphorylations of Akt and ERK, which were suppressed by CCR5 knockdown. Migration and invasion of ESCC cells were promoted by ...
In vitro CCL3 stimulated fibroblasts to express HGF. Collectively, the CCL3-CCR5 axis appears to regulate intratumoral trafficking of leukocytes and fibroblasts, as well as MMP-9 and HGF expression, and as a consequence to accelerate neovascularization and subsequent metastasis formation. 展开 ...
目的:目前证据表明免疫应答在神经损伤中有重要作用,脊髓胶质细胞,IL-4(白介素-4),CCL3及其受体CCR5,p38MAPK信号通路都参与了神经炎症反应和神经病理性疼痛.因此,本研究旨在探讨IL-4/CCL3/CCR5在神经病理性疼痛中的作用,...
摘要 目的评价瑞芬太尼诱发切口痛大鼠痛觉过敏时脊髓趋化因子配体3(CCL3)和趋化因子CC亚族受体5(CCR5)表达水平的变化。方法雄性SD大鼠32只,体重240~260 g,2~3月龄,采用随机数字表法,分为4组(n=8):对照组(C组)、切口痛组(I组)、瑞芬太尼组(R组)和瑞芬太尼+切口痛组(R+I组)。于切口痛模型制备的...
目的 通过功能磁共振成像鉴定骨关节炎的不同阶段并探讨趋化因子CCL2/CCL3及受体CCR5的表达.方法 选取因骨关节炎(osteoarthritis,OA)行人工全膝关节置换术(total knee arthroplasty,TKA)患者的离体股骨髁软骨标本,进行超短回波磁共振成像(ultrashort echo magnetic resonance imaging,UTE MRI)扫描.标本扫描结束后行Safan...
Polymorphisms in CCR5, the major coreceptor for HIV, and CCL3L1, a potent CCR5 ligand and HIV-suppressive chemokine, are determinants of HIV-AIDS susceptibility. Here, we mathematically modeled the potential impact of these genetic factors on the epidemic spread of HIV, as well as on its ...
CCL3 (MIP-1α), a prototype of CC chemokines, is a potent chemoattractant toward human neutrophils pre-treated with GM-CSF for 15 min. GM-CSF-treated neutrophils migrate also to the selective CCR5 agonist CCL4 ?MIP-1β). CCL3- and CCL4-triggered migration of GM-CSF-primed neutrophils was...
Furthermore, as reconstitution of CD4(+) cells during HAART is more sensitive to CCL3L1 dose than to CCR5 genotypes, CCL3L1 analogs might be efficacious in supporting immunological reconstitution. 展开 关键词: Alleles Antiretroviral Therapy, Highly Active CD4 Lymphocyte Count Chemokines, CC 等位基因...
CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms. Nat. Immunol. 8:1324-1336.Dolan M, Kulkarni H, Camargo J, et al: CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-...
Mueller A. Strange PG CCL3, acting via the chemokine receptor CCR5, leads to inde- pendent activation of Janus kinase 2 (JAK2) and Gi proteins. FEBS Lett 2004;570: 126-132.Mueller, A, Strange, PG (2004a) CCL3, acting via the chemokine receptor CCR5, leads to independent activation of...