CCL3/CCR1 axisCD14(+)CD16(−)knee osteoarthritismonocytesObjectives: Monocyte-derived macrophages, as the predominant immune cell type that is increased in inflamed synovium, play a vital role during knee osteoarthritis (KOA) progression. However, the mechanisms underlying the recruitment of ...
We demonstrate a novel pro-inflammatory role for CCL3/MIP-1α since CCL3/MIP-1α deficiency significantly attenuated hepatic injury, both biochemically and histologically. Moreover, the recruitment of CCR1-expressing CD4+ T cells to the liver after Con A treatment was strikingly attenuated ...
CCL3/CCR1 axisCCL2/CCR2 axisCD14(+)CD16(-)MonocytesKnee osteoarthritisObjectives: Monocyte-derived macrophages, as the predominant immune cell type that is increased in inflamed synovium, play a vital role during knee osteoarthritis (KOA) progression. However, the mechanisms underlying the ...
CCR1 receptor antagonists; inhibitors of MIP-1 alpha (CCL3) binding to its receptor CCR1 found on inflammatory and immunomodulatory cells; macrophage inflammatory protein (MIP)doi:US6974817 B2A compound of the formula or the pharmaceutically acceptable salt thereof; wherein X, Y, a, b, c, d...
PS2-059. Essential roles of CCL3-CCR1 axis in the pathogenesis of antigen-induced arthritisdoi:10.1016/j.cyto.2011.08.002Toshikazu Kondo and Yuko Ishida and Masanori Inui and Akihiko Kimura and Mizuho Nosaka and Yumi Kuninaka and Mariko Kawaguchi and Naofumi Mukaida...
Yang X, Lu P, Fujii C, Nakamoto Y, Gao JL, Kaneko S et al. (2006). Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression. Int J Cancer 118: 1869-1876.Yang X,Lu P,Fujii C,et al.Essential contribution of a chemo-kine,CCL3,...
MIP-1alpha[CCL3] acting on the CCR1 receptor mediates neutrophil migration in immune inflammation via sequential release of TNF-alpha and LTB4. J. Leukoc. Biol. 78: 167-177.Ramos CD, Canetti C, Souto JT, Silva JS, Hogaboam CM, Ferreira SH, Cunha FQ. MIP-1alpha[CCL3] acting on ...
(2006). Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression. Int. J. Cancer 118, 1869-1876.Yang X,Lu P,Fujii C,et al.Essential contribution of a chemo-kine,CCL3,and its receptor,CCR1,to hepatocellular carcinoma progression....
CCL3/MIP-1 is pro-inflammatory in murine T cell-mediated hepatitis by recruiting CCR1-expressing CD4+ T cells to the liver G. (2004) CCL3/MIP-1␣ is pro-inflammatory in murine T cell-mediated hepatitis by recruiting CCR1-expressing CD4(ϩ) T cells to the liver. Eur... MN ...
In patients with BD, plasma levels of CCL3 in an active state were significantly higher than in healthy control individuals (P = 0 center dot 02). These results show that the up-regulation of CCR1(+) cells was related to the control of systemic inflammation of BD in mouse models.Sayeed...