CCL3/CCR1 axisCD14(+)CD16(−)knee osteoarthritismonocytesObjectives: Monocyte-derived macrophages, as the predominant immune cell type that is increased in inflamed synovium, play a vital role during knee osteoarthritis (KOA) progression. However, the mechanisms underlying the recruitment of ...
目的:研究桑杏清营汤通过调控放射性肺损伤趋化因子CCL3/CCR1通路产生疗效的作用机制,为临床治疗放射性肺损伤提供新的治疗思路,也为进一步从伏气温病角度研究放射性肺损伤提供实验依据。方法:采用直线加速器6MV-X线(照距SSD为1m,剂量率为200cGy/min)对SD大鼠进行放射性肺损伤造模;病理观察桑杏清营汤对RILI模型大鼠...
CCL3/MIP-1 is pro-inflammatory in murine T cell-mediated hepatitis by recruiting CCR1-expressing CD4+ T cells to the liver G. (2004) CCL3/MIP-1␣ is pro-inflammatory in murine T cell-mediated hepatitis by recruiting CCR1-expressing CD4(ϩ) T cells to the liver. Eur... MN ...
G. (2004). CCL3/MIP-1α is pro-inflammatory in murine T cell-mediated hepatitis by recruiting CCR1-expressing CD4+ T cells to the liver. Eur. J. Immunol. 34, 2907-2918. doi: 10.1002/eji.200425071Ajuebor MN, Hogaboam CM, Le T, Proudfoot AE, Swain MG. CCL3/MIP-1alpha is pro-...
CCL3/CCR1 axisCCL2/CCR2 axisCD14(+)CD16(-)MonocytesKnee osteoarthritisObjectives: Monocyte-derived macrophages, as the predominant immune cell type that is increased in inflamed synovium, play a vital role during knee osteoarthritis (KOA) progression. However, the mechanisms underlying the ...
PS2-059. Essential roles of CCL3-CCR1 axis in the pathogenesis of antigen-induced arthritisdoi:10.1016/j.cyto.2011.08.002Toshikazu Kondo and Yuko Ishida and Masanori Inui and Akihiko Kimura and Mizuho Nosaka and Yumi Kuninaka and Mariko Kawaguchi and Naofumi Mukaida...
Pretreatment of macrophages with an antagonist of CCR1, the primary receptor for CCL3 and CCL4, blocked cytokine-mediated migration. Conclusion Our findings indicate that TNFα and IL-1β modulate the expression of CCL3 in NP cells by controlling the activation of MAPK, NF-κB, and C/EBPβ...
CCL3/MIP-1␣ is pro-inflammatory in murine T cell-mediated hepatitis by recruiting CCR1-expressing CD4ϩ T cells to the liver. Eur. J. Immunol. 34:2907-2918.Ajuebor MN, Hogaboam CM, Le T, Proudfoot AE, Swain MG (2004) CCL3/MIP-1alpha is pro-inflammatory i...
In patients with BD, plasma levels of CCL3 in an active state were significantly higher than in healthy control individuals (P = 0 center dot 02). These results show that the up-regulation of CCR1(+) cells was related to the control of systemic inflammation of BD in mouse models.Sayeed...
CCR1 receptor antagonists; inhibitors of MIP-1 alpha (CCL3) binding to its receptor CCR1 found on inflammatory and immunomodulatory cells; macrophage inflammatory protein (MIP)doi:US6974817 B2A compound of the formula or the pharmaceutically acceptable salt thereof; wherein X, Y, a, b, c, d...