The genetic diversity of C-C motif chemokine receptor 5 (CCR5) ligands CCL3, CCL4 and CCL5 in the leporid genera Oryctolagus, Sylvilagus and Lepus was studied. Our results demonstrate that the three CCR5 chemokine ligands are under strong purifying selection as a result of possible functional ...
趋化因子(C-C motif)配体3(CCL3),也称为巨噬细胞炎症蛋白1α(MIP-1α),是一种小细胞因子,属于C-C趋化因子家族的成员。与CCL4/MIP-1β密切相关。CCL3通过与CCR1、CCR3和CCR5的相互作用发挥其生物学功能。CCL3在抗原或丝裂原刺激后主要表达于T细胞、B细胞和单核细胞。CCL3促进许多造血细胞类型的吸引、粘附...
趋化因子(C-C motif)配体3(CCL3),也称为巨噬细胞炎症蛋白1α(MIP-1α),是一种小细胞因子,属于C-C趋化因子家族的成员。与CCL4/MIP-1β密切相关。CCL3通过与CCR1、CCR3和CCR5的相互作用发挥其生物学功能。CCL3在抗原或丝裂原刺激后主要表达于T细胞、B细胞和单核细胞。CCL3促进许多造血细胞类型的吸引、粘附...
which are shared with CCL4 and CCL5 (RANTES). CCR5 is the primary co-receptor for HIV entry, which the virus binds through the gp120 envelope protein. All CCR5 ligands demonstrate potent inhibition of virus entry into the cell, both through steric hindrance of gp120-CCR5 interaction, and li...
第一部分,趋化因子CCL3L1,CCL4L1基因多态性与肝移植术后急性排斥反应与乙肝复发的关系 目的:探讨CCL3L1, CCL4L1基因拷贝数变异与单核苷酸多态性与在肝移植术后排斥反应的风险与乙肝复发的关系. 方法:选取266中国汉族肝移植患者以及其中185例乙肝病毒感染相关终末期肝病肝移植患者列入本项研究.以试剂盒从外周血提取基...
CCL3 signaling is mediated by the G protein-coupled receptors CCR1, CCR4, and CCR5, which are shared with CCL4 and CCL5 (RANTES).Applications Reported: This DNT3CC antibody has been reported for use in intracellular staining followed by flow cytometric analysis.Applications Tested: T...
GM-CSF-treated neutrophils migrate also to the selective CCR5 agonist CCL4 ?MIP-1β). CCL3- and CCL4-triggered migration of GM-CSF-primed neutrophils was inhibited by the CCR5 antagonist TAK-779. Accordingly, freshly isolated neutrophils express CCR5. Extracellular signal-regulated kinases (ERK)-...
CCL3 signaling is mediated by the G protein-coupled receptors CCR1, CCR4, and CCR5, which are shared with CCL4 and CCL5 (RANTES). CCR5 is the primary co-receptor for HIV entry, which it binds through the gp120 envelope protein. All CCR5 ligands demonstrate potent inhibition of virus entry...
1A). In addition, the CCR5 and VEGF-A are localized in nucleus and cell membrane (Fig. 1A). We examined whether CCL3-induced VEGF-A expression and angiogenesis through CCR5 receptor. Pretreated cells with CCR5 monoclonal antibody (mAb) or the CCR5 antagonist (DAPTA) significantly reduced CCL...
Gene polymorphisms of CCL3, CCL4, CCL5, and CCR5 network in metastatic colorectal cancer patients treated with regorafenib 199 Background: We previously reported that genetic variant in the CCL5/CCR5 pathway predict efficacy of regorafenib in metastatic colorectal cancer patients (mCRC). CCL5 rs228...