Degrades chromatin by cleavage between the histone-DNA complex of the nucleosomes during apoptosis. caspase , DNase , nucleosome , chromatin , ICAD , ACINUS , apoptosis , ICAD , endonuclease G ; Enari M et al 1998 Nature [Lond] 391:43.Springer Netherlands...
建议收到CAD (Caspase Activated Dnase) BioAssay ELISA Kit (Mouse)产品后将其置于4°C/-20°C保存。 其他 Usbiological公司是美国著名的抗体和生化试剂供应商,生产世界上种类最多的抗体,用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、...
【答案】:Caspase活化的DNA酶(Caspase activated DNase,CAD):通常情况下与其抑制因子ICAD结合处于失活状态。细胞凋亡程序启动后,活化的Caspase-3降解ICAD,使CAD释放出来并在核小体间切割DNA,形成间隔200bp或其整倍数的DNA片段。 已赞过 你对这个回答的评价是? 评论 收起 为你推荐:下载百度知道APP,抢鲜体验 使用百...
上海玉博生物科技有限公司主要致力于“Caspase Activated Dnase (Cad) Polyclonal Antibody CAU26593”的生产销售。多年的“Caspase Activated Dnase (Cad) Polyclonal Antibody CAU26593”生产与销售的经验,与各行业新老用户建立了稳定的合作关系,我公司经营的产品名称深
Caspases also cleave regulatory proteins such as Bcl family members and the inhibitor of caspase-activated DNase (ICAD). Cleavage of ICAD leads to the release of active CAD, which enters the nucleus and cleaves nucleosomes at the linker region, yielding the characteristic “DNA ladder.” Not ...
Key words CAD (caspase-activated-DNaseDinucleotide repeatSNPsCaspase-activated DNase (CAD) cleaves chromosomal DNA during apoptosis. We determined its genomic structure and identified single-nucleotide polymorphisms (SNPs) within exons 5 and 7, as well as a highly polymorphic dinucleotide repeat of (CT...
CAD (caspase-activated DNase) that causes chromosomal DNA fragmentation during apoptosis exists as a complex with ICAD (inhibitor of CAD) in proliferating cells. Here, we report that denatured CAD is functionally refolded with Hsc70-Hsp40 and ICAD. Hsc70-Hsp40 suppresses the aggregation of the ...
Here, we examined whether caspase-activated DNase (CAD) is responsible for the DNA fragmentation that occurs upon exposure to various apoptotic stimuli. When human Jurkat cells were exposed to etoposide, or UV or radiation, a caspase-3-like protease was activated, and nuclear DNA was fragmented...
;SOLUTION: This enzyme is a new DNase (CAD) selected from a protein having an amino acid sequence of the formula, and a protein having an amino acid sequence of the formula having the deficiency, substitution and/or insertion of one or plural amino acids, and having the same DNase ...
Inhibitor of caspase-activated DNase (ICAD) is required for correctly folding of CAD and inhibits nuclease activity of CAD in non-apoptotic cells. From proteomic analysis of the ICAD binding proteins, we revealed that over-expressed flag-ICAD bound other ICAD molecules}. Purified recombinant ICAD ...