1. Ross, Connie et al. “Inflammatory Caspases: Toward a Unified Model for Caspase Activation by Inflammasomes.” Annual review of immunology vol. 40 (2022): 249-269. doi:10.1146/annurev-immunol-101220-030653 2. Boucher, Dave et al. “Caspase-1 self-cleavage is an intrinsic mechanism to ...
Caspase-1 activation by Salmonella., ArtículoSalmonella is an interesting example of how the selective pressure of host environments has led to the evolution of sophisticated bacterial virulence mechanisms. This microbe exploits the first-line of defence, the macrophage, as a crucial tool in the ...
The study of mechanisms by which Salmonella induces programmed cell death offers new insights into how pathogens cause disease and into general mechanisms of activation of the innate immune system. 展开 关键词: Caspase-1 activation by Salmonella., Artículo ...
Inflammasome Activation TriggersCaspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA VirusInfection 文献摘要: 病毒感染会诱发宿主的天然免疫应答,产生各种细胞因子,例如IFN-I,激活炎性小体,触发感染细胞的程序性死亡。严格调控炎性细胞因子的产生对于控制感染的同时又不损伤宿主,有着重要的意义。作者研...
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes secretion of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18, as well as 'pyroptosis', a form of cell death induced by bacterial pathogens. Members of the Nod-like receptor ...
The inflammasome is an innate immune signaling platform leading to caspase-1 activation, maturation of pro-inflammatory cytokines and cell death. Recognition of DNA within the host cytosol induces the formation of a large complex composed of the AIM2 receptor, the ASC adaptor and the caspase-1 ef...
Caspase-1 activation was required for cytokines production.Caspase-1 activation was required for cytokines production.Lin, JingShou, XilingMao, XiaoboDong, JiangchuanMohabeer, Nileshkumar Kushwaha, KishanWang, LeiSu, YousuFang, HongchengLi, Dazhu...
Western Blot (see online protocol):(1μg/ml) (no need to precipitate the cell supernatant for the detection of caspase-1 (mouse) upon inflammasome activation) Immunohistochemistry:(1:500; paraffin sections) Immunoprecipitation:(1:200) CrossreactivityMouse ...
Activation of caspase-1 in the nucleus requires nuclear translocation of pro-caspase-1 mediated by its prodomain. PL Mao - 《Journal of Biological Chemistry》 被引量: 0发表: 1998年 Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1. Caspase-9-mediated ...
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