参考文献: 1. Ross, Connie et al. “Inflammatory Caspases: Toward a Unified Model for Caspase Activation by Inflammasomes.” Annual review of immunology vol. 40 (2022): 249-269. doi:10.1146/annurev-immunol-101220-030653 2....
Caspase-1 activation by Salmonella., ArtículoSalmonella is an interesting example of how the selective pressure of host environments has led to the evolution of sophisticated bacterial virulence mechanisms. This microbe exploits the first-line of defence, the macrophage, as a crucial tool in the ...
The study of mechanisms by which Salmonella induces programmed cell death offers new insights into how pathogens cause disease and into general mechanisms of activation of the innate immune system. 展开 关键词: Caspase-1 activation by Salmonella., Artículo ...
作者研究了利用DNA病毒感染ASC-/-与Casp-/巨噬细胞,发现这两个分子的缺陷会导致IFN的产生增加,但RNA病毒的感染却未有此表型。针对这种表型的机制研究结果表明,一旦经典(canonical)炎性小体或非经典(non-canonical)炎性小体活化,那么caspase-1就会与细胞质中的GMP-AMP(cGAMP)合成酶(cGAS)相互作用,将cGAS酶解(cleav...
16kAccesses 20Altmetric Metrics Abstract The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes secretion of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18, as well as 'pyroptosis', a form of cell death induced by bacterial pathogens...
(10 kD) subunits. The active caspase-1 is a heterotetramer consisting of two large and two small subunits. To date the regulatory mechanism of caspase-1 activation and the role of caspase-1 in apoptosis are poorly understood. In THP-1 cells, a large proportion of the caspase-1 is ...
Pannexin-1-dependent caspase-1 activation and secretion of IL-1β is regulated by zinc Inflammatory processes induced by IL-1 are critical for host defence responses, but are also implicated in disease. Zinc deficiency is a common consequence... D Brough,P Pelegrin,NJ Rothwell - 《European Jou...
Generation of a Listeria vaccine strain by enhanced caspase-1 activation. Eur J Immunol 41: 1934 -1940, 2011.Warren SE, Duong H, Mao DP, Armstrong A, Rajan J et al. (2011) Generation of a Listeria vaccine strain by enhanced caspase-1 activation . Eur J Immunol 41 : 1934-1940. ...
IF=30.9, 《Escherichia coli Rho GTPase-activating toxin CNF1 mediates NLRP3 inflammasome activation via p21-activated kinases-1/2 during bacteraemia in mice》,Nature Microbiology FLICA®相关产品列表,相关靶标:Caspase-1 (YVAD) (also recognizes caspases 4 and 5), -2 (VDVAD), -3/7 (DEVD),...
[2] Putinski C,Abdul-Ghani M,Stiles R,Brunette S,Dick SA,Fernando P,Megeney LA(2013)."Intrinsic-mediated caspase activation is essential for cardiomyocyte hypertrophy".Proceedings of the National Academy of Sciences.110(43):E4079–87.