Cardiac dysfunction during sepsis is due, at least in part, to cardiac energy deficiency. It has been discovered that lipopolysaccharide (LPS)-mediated cardiac dysfunction is prevented or treated by treatments that improve FA oxidation (FAO), despite the persistence of inflammation. The present ...
Sepsis-induced myocardial dysfunction represents a major cause of death in intensive care units. Alamandine is an important biologically active peptide in the renin-angiotensin system. The present study evaluated whether alamandine improves cardiac dysfunction, inflammation, and apoptosis, and affects the ...
β-arrestin 2 modulates cell survival and cell death in different systems. However, the effect of β-arrestin 2 on sepsis-induced cardiac dysfunction is not yet known. Here, we show that β-arrestin 2 overexpression significantly enhances animal survival following cecal ligation and puncture (CLP)...
LPS increased ICA69 in vivo while in vitro To assess the underlying function of ICA69 in sepsis-induced heart dysfunction, our team studied the levels of ICA69 and the infiltration of macrophages in LPS heart lesion. Firstly, our team carried out quantitative real-time PCR and western blot ob...
The immune response gene 1 (IRG1) and its metabolite itaconate are implicated in modulating inflammation and oxidative stress, with potential relevance to sepsis-induced myocardial dysfunction (SIMD). This study investigates their roles in SIMD using both in vivo and in vitro models. Mice were subj...
Characterization of cardiac dysfunction in sepsis: an ongoing challenge. Shock. 2014;41(1):12–24. Article PubMed Google Scholar Benes J, Chvojka J, Sykora R, Radej J, Krouzecky A, Novak I, et al. Searching for mechanisms that matter in early septic acute kidney injury: an ...
cardiac dysfunction, and mortality in vivo. Indeed, PGE2signaling via EP2/4 receptors mediates excessive ACh release, which in turn causes the heart failure of envenomed mice. Of importance, we introduce a novel pathway that is targeted by dexamethasone, but not by anti-scorpion venom serum. Tak...
Enhanced glycolytic metabolism contributes to cardiac dysfunction in polymicrobial sepsis. J. Infect. Dis. 215, 1396–1406 (2017). Article CAS PubMed PubMed Central Google Scholar Sen, S. et al. Glucose regulation of load-induced mTOR signaling and ER stress in mammalian heart. J. Am. ...
A review of sepsis-induced cardiomyopathy. J. Intensive Care 3, 48 (2015). PubMed PubMed Central Google Scholar Krishnagopalan, S., Kumar, A., Parrillo, J. E. & Kumar, A. Myocardial dysfunction in the patient with sepsis. Curr. Opin. Crit. Care 8, 376–388 (2002). PubMed ...
Cardiomyocyte pyroptosis is a primary contributor to sepsis-induced cardiac dysfunction (SICD). Recombinant phospholipid transfer protein (PLTP) have been demonstrated to possess anti-inflammatory and antiseptic properties. However, the effect of PLTP on SICD remains unknown. In this study, we establish...