Evaluation of the effect of sepsis on intermediate metabolism on heart and skeletal muscle using carbon(13) NMR spectroscopy.Sepsis is the systemic response of the body to the severe infection characterized by the presence of bacteria in the circulation bloodstream. It is now the leading cause of...
Effect of inhaled nitric oxide on pulmonary function after sepsis in a swine model Inhaled nitric oxide (NO) has been shown to improve sepsis induced pulmonary dysfunction. This study evaluated the mechanism by which inhaled NO improves p... H Ogura,WG Cioffi,PJ Offner,... - 《Surgery》 被...
Upregulation of programmed cell death protein 1 (PD-1) on neutrophils may be associated with sepsis-induced immunosuppression [106]. Huang et al. have demonstrated that the survival of PD-1−/− mice is improved in a mouse model of sepsis induced by the cecal ligation-and-puncture procedu...
Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial. JAMA. 2013;310(16):1683-1691.ArticlePubMedGoogle ScholarCrossref 29. Ebert TJ, Hall JE, Barney JA, Uhrich TD, Colinco MD. The effects of increasing ...
31 whereas others showed that sepsis did not have any significant effect on cerebral vascular function.32,33 Rat models of sepsis show increased permeability of the BBB in sepsis, as detected by increased horseradish peroxidase staining of CNS samples taken from septic rats, compared with controls....
The formation of vegetation on heart valves can result in valve dysfunction and the spread of bacteria throughout the bloodstream, leading to sepsis and DIC [20,21]. Another theory proposes that DIC occurs because of the release of cytokines and other signaling molecules in response to the ...
Another reported toxic effect is digital or mesenteric ischemia, which has been demonstrated in porcine models at doses above 0.4 U/min [120]. Myocardial ischemia has been studied by measuring biomarkers of myocardial damage 12 h after heart surgery, with no differences being found when comparing...
10 In effect, the definitions of sepsis, septic shock, and organ dysfunction have remained largely unchanged for more than 2 decades.Box 1. SIRS (Systemic Inflammatory Response Syndrome) Two or more of: Temperature >38°C or <36°C Heart rate >90/min...
In the present study, we determined the effect of chronic peritoneal sepsis on the mechanical properties and intracellular Ca2+ handling of cardiac myocytes isolated from septic rats at 24 or 48 h. Mechanical properties were evaluated by use of an IonOptix MyoCam system. Myocytes were electrically...
[9] Andrews B, Semler MW, Muchemwa L, et al. Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and Hypotension: A Randomized Clinical Trial[J]. JAMA, 2017, 318(13):1233-1240. [10] Kelm DJ, Perrin JT, Cartin-Ceba R, et al. Fluid overload...