[3]Li C,et al.Robo1-specific chimeric antigen receptor natural killer cell therapy for pancreatic ductal adenocarcinoma with liver linkstasis[J]. Journal of Cancer Research and Therapeutics, 2020, 16(2): 393-396.https://journals.lww.com/cancerjournal/fulltext/2020/16020/robo1_specific_chimeric...
[1]Marin D,et al.Safety,efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19+B cell tumors: a phase 1/2 trial. Nat Med. 2024 Mar;30(3):772-784.https://www.nature.com/articles/s41591-023-02785-8 [2]Sauter C S,et al.A Phase 1 Study of NKX1...
Investigation of the efficacy and feasibility of combined therapy of PD‐L1‐enhanced exogenous peripatetic adoptive natural killer (NK) cells in combination with antiangiogenic targeted therapy in the treatment of extensive‐stage smal...
相比于传统的CAR-T疗法，这些“NK特种兵”不需要“先练个几年功夫再上场”。它们生来就有对癌细胞的敏感性，加上经过基因工程“武装升级”，能迅速锁定并消灭目标。据《Cell Reports》的一项数据，CAR-NK的开发周期比CAR-T短了约30%，治疗成本降低了将近50%。二、CAR-NK疗法的“性价比”：为什么它更香？在...
图4. CAR-engineeredNK cell 双特异性分子联结NK细胞活化受体和肿瘤细胞 如图5所示,以NK细胞表面活化受体CD16和NKG2D为靶点的双特异性分子,可以靶向NK细胞识别并杀伤肿瘤细胞。 图5. 双特异分子联结NK活化受体和肿瘤细胞 以NK细胞为基础的肿瘤免疫治疗 NK细胞在免疫监视中扮演着非常重要的角色,随着对NK细胞的分子...
Colorectal Cancer Patients. Mol Ther. 2019 Jun 5;27(6):1114-1125.https://pmc.ncbi.nlm.nih.gov/articles/PMC6554529/ [5]https://immunitybio.com/first-patients-dosed-in-phase-1-clinical-study-of-immunitybios-car-nk-cell-therapy-for-the-treatment-of-relapsed-b-cell-non-hodgkin-lymphoma/ ...
[1]Marin D,,et al.Safety,efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19+B cell tumors: a phase 1/2 trial. Nat Med. 2024 Mar;30(3):772-784. doi: 10.1038/s41591-023-...
CAR-NK细胞疗法作为抗癌领域的新兴疗法，被业内寄予厚望，但目前仍在临床试验阶段。虽然部分临床试验取得了可观的疗效，但仍具有改善的空间。随着临床研究的不断深入，CAR-NK细胞疗法将会是一个有效且安全的治疗方案。参考资料 1.Advances in CAR-NK cell therapy for lung cancer: is it a better choice in the ...
CAR-T细胞：CAR-T细胞主要应用于血液系统恶性肿瘤，如白血病和淋巴瘤。这些肿瘤通常表达特定的抗原，使得CAR-T细胞能够高效地识别并攻击它们。《Cancer Cell》杂志上的一项研究指出，CAR-T细胞在血液系统恶性肿瘤中的应用已经取得了显著的进展。CAR-NK细胞：CAR-NK细胞不仅应用于血液系统恶性肿瘤，还有望应用于实体瘤。NK...
1. Safety, efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19+ B cell tumors: a phase 1/2 trial | Nature Medicine 2. Natural killer cell therapies | Nature 3. CAR-NK cells: A promising cellular immunotherapy for cancer - eBioMedicine (thelancet.com)4....