Recent advances and discoveries in the mechanisms and functions of CAR T cells本篇文章给大家展示了过去3年中嵌合抗原受体 (CAR) T 细胞在功效和安全性等方面的主要进展和变化，CAR的各种分子模块如何影响信号传导和功能，在CAR-T治疗过程中会发生的毒副作用以及如何干预以最大程度的降低毒副作用。接下来我们一...
经过不断的技术改进和严格的临床监护管理目前已经可以有效的控制CAR-T的副反应,CAR-T疗法治疗癌症的数量逐渐增多;CAR-T在白血病、淋巴瘤等血液类疾病中临床表现良好,但在血液肿瘤相关领域靶点扎堆的现状也是需要突破的瓶颈之一。目前针对多发骨髓瘤也有了GPRC5D(G蛋白偶联受体...
提高CAR-T细胞的增殖能力、持久性和抗瘤活性,可在CAR-T细胞上表达IL-7受体; 改变T细胞终末状态的分化,研究表明过表达c-Jun AP1转录因子可以降低T细胞耗竭。 在CAR - T细胞治疗领域的大多数经验是在血液系统恶性肿瘤的环境中,肿瘤微环境(TME)被认为在反应中发挥的作用微乎其微。然而,随着该领域从靶向cd19的CAR-...
Recent advances and discoveries in the mechanisms and functions of CAR T cells 本篇文章给大家展示了过去3年中嵌合抗原受体 (CAR) T 细胞在功效和安全性等方面的主要进展和变化,CAR的各种分子模块如何影响信号传导和功能,在CAR-T治疗过程中会发生的毒副作用以及如何干预以程度的降低毒副作用。 接下来我们一起...
近日，来自澳大利亚彼得·麦卡伦癌症中心的Paul J. Neeson团队在Science Translational Medicine杂志上发表了一篇题为TSTEM-like CAR-T cells exhibit improved persistence and tumor control compared with conventional CAR-T cells in preclinical models 的文章，他们开发了一种生成TSTEM样CAR-T细胞的方案，CAR刺激后...
2021年3月,Nature Review期刊发布了文章《Recent advances and discoveries in the mechanisms and functions of CAR T cells》,阐述了CAR-T细胞作用机理的最新进展和发现。“细胞知聊”将分几期来介绍相关内容。 今天小编为大家带来的是,嵌合抗...
CAR T cells improved 4-year overall survival in patients with large B-cell lymphoma (54.6% vs 46.0%). Patients with pediatric acute lymphoblastic leukemia achieved durable remission after CAR T-cell therapy. At 3-year follow-up, 48% of patients were alive and relapse free. In ...
Here, we review protein- and cell-engineering strategies that seek to overcome these obstacles and produce next-generation T cells with enhanced tumour specificity and sustained effector function for the treatment of solid malignancies. This is a preview of subscription content, access via your ...
一些研究旨在改变和操纵CD28信号传导通过修饰CD28结构域中酪氨酸免疫受体的激活基序。 原文来源: REVIEWTherapeutic roles of CAR T cells in infectious diseases: Clinical lessons learnt from cancer.DOI: 10.1002/rmv.2325 请注明:姓名+研究方向! 版 权 声 明...
This Review discusses the major advances and changes made over the past 3 years to our understanding of chimeric antigen receptor (CAR) T cell efficacy and safety. Recently, the field has gained insight into how various molecular modules of the CAR in