This article has been updatedAbstract Chimeric antigen receptor (CAR) T cell therapies have evolved from a research tool to a concept-shifting therapy with impressive responses in B cell malignancies. This Review summarizes the current state of the CAR T cell field, focusing on CD19- and B ...
Despite several therapeutic advances over the past decade, multiple myeloma (MM) remains largely incurable, indicating a need for new treatment approaches. Chimeric antigen receptor (CAR) T cell therapy works by mechanisms distinct from those of other MM
Significant advances have been made in chimeric antigen receptor T (CAR-T)-cell therapy for the treatment of recurrent or refractory B-cell hematologic malignancies. However, CAR-T-cell therapy has not yet achieved comparable success in the management of
In recent decades, the advent of immune-based therapies, most notably Chimeric antigen receptor (CAR)-T cell therapy has revolutionized cancer treatment. The promising results of numerous studies indicate that CAR-T cell therapy has had a remarkable ability and successful performance in treating blood...
Stem Cell Research & Therapy Home About Articles Submission Guidelines Submit manuscript Review Open access Published: 25 January 2021 CAR T cells in solid tumors: challenges and opportunitiesFaroogh Marofi, Roza Motavalli, Vladimir A. Safonov, Lakshmi Thangavelu, Alexei Valerievich Yumashev, ...
Chimeric antigen receptor (CAR) T cell therapy has emerged as a novel therapeutic T cell engineering practice, in which T cells derived from patient blood are engineered in vitro to express artificial receptors targeted to a specific tumor antigen. These directly identify the tumor antigen without ...
“Natural T-cell function isn’t good enough. We need to explore theextremes of T-cell function,” says Kole Roybal, animmunologistat the University of California, San Francisco, and co-author of the new paper. What better place to start than with the mutations that turn healthy T cells...
2024年2月22日,德国埃尔朗根-纽伦堡大学(FAU)的Georg Schett教授团队在《新英格兰医学杂志》(NEJM)上发表了题为:CD19 CAR T-Cell Therapy in Autoimmune Disease — A Case Series with Follow-up的研究论文【1】。 该论文报道了15名自身免疫病患者(8名系统性红斑狼疮患者、4名系统性硬化症患者和3名特发性炎...
[2] City of Hope scientists uncover protein that helps cancer cells dodge CAR T cell therapy. Retrieved Dec. 24, 2024 from https://www.cityofhope.org/city-of-hope-scientists-uncover-protein-that-helps-cancer-cells-dodge-car-t-cell-therapy 免责声明：药明康德内容团队专注介绍全球生物医药健康研究...
CAR T cell therapy in solid tumors: a review of current clinical trials. EJHaem 3, 24–31 (2022). PubMed Google Scholar Labanieh, L. & Mackall, C. L. CAR immune cells: design principles, resistance and the next generation. Nature 614, 635–648 (2023). CAS PubMed Google Scholar ...