Of note, less than 10% of the ongoing CAR T cell clinical trials are performed in Europe. Taking lead from our analysis, we discuss the problems and general hurdles preventing efficient clinical development of CAR T cells as well as opportunities, with a special focus on the European stage....
为了制造这种名为 Co-STAR(Co-stimulatory Synthetic T-cell receptor and Antigen Receptor, 协同刺激合成 T 细胞受体和抗原受体)的细胞,这些作者将机体通常用来抵御入侵者的四种细胞的基因成分---来自T细胞的T细胞受体(TCR)、来自B细胞的抗体、来自称为单核细胞的白细胞的MyD88以及来自树突细胞和其他细胞的CD40---...
为了制造这种名为 Co-STAR(Co-stimulatory Synthetic T-cell receptor and Antigen Receptor, 协同刺激合成 T 细胞受体和抗原受体)的细胞,这些作者将机体通常用来抵御入侵者的四种细胞的基因成分---来自T细胞的T细胞受体(TCR)、来自B细胞的抗体、来自称为单核细胞的白细胞的MyD88以及来自树突细胞和其他细胞的CD40---...
为了制造这种名为 Co-STAR(Co-stimulatory Synthetic T-cell receptor and Antigen Receptor, 协同刺激合成 T 细胞受体和抗原受体)的细胞,这些作者将机体通常用来抵御入侵者的四种细胞的基因成分---来自T细胞的T细胞受体(TCR)、来自B细胞的抗体、来自称为单核细胞的白细胞的MyD88以及来自树突细胞和其他细胞的CD40---...
相关研究结果近期发表在Molecular Therapy-Methods & Clinical Development期刊上,论文标题为“Metabolic priming of GD2 TRAC-CAR T cells during manufacturing promotes memory phenotypes while enhancing persistence”。 T细胞,作为免疫系统中对抗...
[1] Wei J , Guo Y , Wang Y , et al. Clinical development of CAR T cell therapy in China: 2020 update[J]. Cellular & Molecular Immunology, 2020:1-13. [2] Han D, Xu Z, Zhuang Y, Ye Z, Qian Q. Current Progress in CAR-T Cell Therapy for Hematological Malignancies. J Cancer....
此外,传奇生物 CAR-T 疗法 LCAR-B38M 预计于 2021 年提交上市申请。 参考文献: 1.Wei J, Guo Y, et al. Clinical development of CAR T cell therapy in China: 2020 update. Cell Mol Immunol. 2020 Sep 30. doi: 10.1038/s41423-020-00555-x....
这种独特的结构使得CAR-T细胞不会受传统T细胞受体（T cell receptor，TCR）与主要组织相容性复合体（Major histocompatibility complex，MHC）间的相互作用而限制，同时让CAR-T细胞针对癌细胞表现出细胞毒性。不依赖MHC识别靶细胞是CAR-T疗法的基本优势，这一特性使得该疗法适用于多种癌症类型。传统的免疫反应依赖于MHC分子...
Chimeric antigen receptor (CAR) T-cell therapy has achieved significant success in the treatment of hematological malignancies. In recent years, fast-growing CAR T clinical trials have actively explored their potential application scenarios. According to
Jianshu Wei et al. Clinical development of CAR T cell therapy in China: 2020 update Cellular & Molecular Immunology 单细胞测序技术是在单个细胞水平上对基因组,转录组,表观组进行高通量测序的新技术,能够揭示单个细胞的基因结构和基因表达状态,是研究细胞异质性的有力工具,近几年越来越多的医药公司将该技术...