Binding of eIF-4E to the 5′ m7G cap structure of eukaryotic mRNA signals the initiation of protein synthesis. In order to investigate the moiecular basis for this recognition, photoaffinity labeling with [γ-32P]8-N3GTP was used in binding site studies of human recombinant cap binding ...
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between 0.3 Å (structure (ii) versus (iii), 367 pairs of C-a atoms) and 0.7 Å (structure (i) versus (iii), 336 pairs of C-a atoms). The structural differences are limited to minor conformational changes of several loops upon substrate binding (Supplementary Fig. S2a). Complex ...
Cap binding and immune evasion revealed by Lassa nucleoprotein structure. Nature 468, 779-783. doi: 10.1038/nature09605Qi X, et al. 2010. Cap binding and immune evasion revealed by Lassa nucleoprotein structure . Nature 468 :779–783Qi X, Lan S, Wang W, Schelde LM, Dong H, Wallat GD,...
To decipher the molecular bases governing seed germination, this study presents the pivotal role of the cap-binding complex (CBC), comprising CBP20 and CBP80, in modulating the inhibitory effects of abscisic acid (ABA) in barley. Using both single and double barley mutants in genes encoding the...
Cap-binding proteins specifically bind to the cap structure and mediate its functions in the cell. Two major cellular cap-binding proteins have been described to date: eukaryotic translation initiation factor 4E (eIF4E) in the cytoplasm and nuclear cap binding complex (nCBC), a nuclear complex ...
how this uncapped RNA is bound tightly by eIF4E, we employ SHAPE probing, phylogenetic comparisons with new PTEs discovered in panico- and carmoviruses, footprinting of the eIF4E binding site, and 3D RNA modeling using NAST, MC-Fold, and MC-Sym to predict a compact, 3D structure of the ...
Protein-DNA recognition complexes: conservation of structure and binding energy in the transition state Biopolymers, 44 (1997), pp. 153-180 View in ScopusGoogle Scholar Jen-Jacobson et al., 2000 L. Jen-Jacobson, L.E. Engler, L.A. Jacobson Structural and thermodynamic strategies for site-speci...
To decipher the molecular bases governing seed germination, this study presents the pivotal role of the cap-binding complex (CBC), comprising CBP20 and CBP80, in modulating the inhibitory effects of abscisic acid (ABA) in barley. Using both single and do
(redirected fromacrosomal cap) Thesaurus Medical Legal Financial Encyclopedia ac·ro·some (ăk′rə-sōm′) n. A caplike structure at the anterior end of a spermatozoon that produces enzymes aiding in egg penetration. [acro-+-some.] ...