Binding of eIF-4E to the 5'm<7>G cap structure of eukaryotic mRNA signals the initiation of protein synthesis. In the present invention, the binding site cap-binding domain of eIF-4E was identified as the region containing the sequence Trp<113> to Arg<122>. Thus, in a first preferred ...
We determined the structure of LGTV NS5 methyltransferase bound to S-adenosyl-L-homocysteine (SAH) at a 1.70 Å resolution. Sequence analysis and structural comparison of homologous MTases suggests that folds and structures are closely conserved throughout Flavivirus species and play important roles...
(B) Domain structure of Crisp proteins. Illustrated are the PR domain (blue), the Hinge domain (red), the ICR domain (green), and variable domains (yellow). Intervening sequences/domains are indicated by parallel lines. The Hinge region (shown in yellow in Fig. 1.10A) is, at 26 ...
Transcription factors (TFs) identification and binding site prediction The PlantRegMap tool was used to predict transcription factors (TFs)100. Promoter sequences, defined as the 1500 bp upstream flanking regions, were retrieved through EnsemblPlants v. 45 using the BioMart tool, based on the Morex...
Transcription factors (TFs) identification and binding site prediction The PlantRegMap tool was used to predict transcription factors (TFs)100. Promoter sequences, defined as the 1500 bp upstream flanking regions, were retrieved through EnsemblPlants v. 45 using the BioMart tool, based on the Morex...
Bottom, secondary structure elements of NCBP3 (aa 120–189) and sequence alignment with human and mouse PARN RRMs. Arrowheads show residues chosen for a mutational analysis. (b) Homology model of the RRM of NCBP3. Secondary structure elements of the predicted RRM fold and residues chosen for ...
interaction model.e) Binding site of TDI-015051 in the complex with SARS-CoV-2 NSP14, SAH, and TDI-015051 overlaid with the structure of SARS-CoV-1 NSP14, SAH, and GpppA. The coordinates for the SARS-CoV-2 and SARS-CoV-1 complexes correspond to PDB ID8R7Band5C8S15, respectively....
Crystal structure of a CAP-DNA complex: the DNA is bent by 90 degrees The 3 angstrom resolution crystal structure of the Escherichia coli catabolite gene activator protein (CAP) complexed with a 30-base pair DNA sequence show... S Schultz,G Shields,T Steitz - 《Science》 被引量: 2023发表...
Structure... Z Wang,M Parisien,K Scheets,... - 《Structure》 被引量: 0发表: 2011年 The 5′‐leader of tobacco mosaic virus promotes translation through enhanced recruitment of eIF4F The 5'-leader sequence (called Omega) of () functions as a translational enhancer in . A poly(CAA) ...
The mRNA cap structure is a major site of dynamic mRNA methylation. mRNA caps exist in either the Cap1 or Cap2 form, depending on the presence of 2′-O-methylation on the first transcribed nucleotide or both the first and second transcribed nucleotides, respectively1,2. However, the identity...