Beyond the Canonical 20 Amino Acids: Expanding the Genetic Lexicon - Young, Schultz () Citation Context ...mino acids can be synthesized ribosomally. A classical strategy to generate peptides (proteins) incorporating one or two non-proteinogenic amino acids is to use triplet stop codons (non-...
www.nature.com/scientificreports OPEN Cell-free synthesis of functional human epidermal growth factor receptor: Investigation of ligand- received: 16 March 2016 independent dimerization in Sf21accepted:07September2016 Published:27September2016 microsomal membranes using non- canonical amino acids Robert B...
Amino acids are essential building blocks in biology and chemistry. Whereas nature relies on a small number of amino acid structures, chemists desire access to a vast range of structurally diverse analogues1–3. The selective modification of amino acid s
Production of non-canonical D-amino acids (NCDAAs) in stationary phase promotes remodelling of peptidoglycan (PG), the polymer that comprises the bacterial... F Cava,MA De Pedro,H Lam,... - 《Embo Journal》 被引量: 187发表: 2014年 Sterol metabolism regulates neuroserpin polymer degradation ...
canonical amino acids as their substrate, however, they can facilitate import of other canonical amino acids and metabolites that have similar chemical structures to the specific substrate26. This allows the hypothesis that some ncAAs can be transported into the cell via the canonical amino acid ...
Incorporation of non-canonical amino acidsL-menthol propionateDiastereoselectivityMolecular dynamics simulationsIt remains a challenge to improve the diastereopreference of an enzymes when there are multiple chiral centers in the substrate, mainly because the limited understanding of mechanism determining ...
Natural evolution has selected a set of 20 canonical genetically encoded amino acids to build a plethora of proteins that provide the biochemical foundations for life. To participate in protein synthesis amino acids require attachment to transfer RNA molecules (tRNAs). This reaction is accomplished by...
Metabolic labeling of proteins with non-canonical amino acids (ncAAs) provides unique bioorthogonal chemical groups during de novo synthesis by taking advantage of both endogenous and heterologous protein synthesis machineries. Labeled proteins can then
(2010) Residuespecific incorporation of non-canonical amino acids into proteins: recent developments and applications. Curr Opin Chem Biol 14: pp. 774-780 CrossRef Furter, R. (1998) Expansion of the genetic code: Site-directed p-fluoro-phenylalanine incorporation in Escherichia coli. Protein Sci...
Extensive breaking of genetic code degeneracy with non-canonical amino acids Clinton A. L. McFeely, Bipasana Shakya, Chelsea A. Makovsky, Aidan K. Haney, T. Ashton Cropp & Matthew C. T. Hartman Nature Communications volume 14, Article number: 5008 (2023) Cite this article 6039 ...