Mini Reviews in Medicinal ChemistryG. Cardillo, L. Gentilucci, A. Tolomelli, Unusual amino acids: synthesis and intro- duction into naturally occurring peptides and biologically active analogues, Mini Rev. Med. Chem. 6 (2006) 293-304.
BA Morgan,JA Gainor - 《Annual Reports in Medicinal Chemistry》 被引量: 317发表: 1989年 Development of conformationally restricted analogues of bradykinin and somatostatin using constrained amino acids and different types of cyclization. The structure-based design of peptide drugs requires the knowledge...
Bicyclobutanes are among the most highly strained isolable organic compounds and their associated low activation barriers to reactivity make them intriguing building-blocks in organic chemistry. In recent years, numerous creative synthetic strategies exp
In contrast, cultured so-called procyclic stage cells, representative of T. brucei living in the insect midgut, rely for their ATP supply largely on mitochondrial catabolism of amino acids and express the enzymes of the tricarboxylic acid cycle and oxidative phosphorylation [5], [12]. For the ...
To our knowledge, only one diterpenoid with a similar skeleton, namely vulgarisin A, derived from the Chinese Medicinal Plant Prunella vulgaris, has been reported to date19. These two novel compounds represented an unprecedented tetracyclo [9.3.0.02,8.03,7] tetradecane ring system from marine ...
F. de Souza Duarte, and M. D. C. De Freire Bastos, "Bacterial labionin-containing peptides and sactibiotics: Unusual types of antimicrobial peptides with potential use in clinical settings (a Review)," Current Topics in Medicinal Chemistry, vol. 17, no. 10, pp. 1177-1198, 2017....
The storage tissues of many plants contain protease inhibitors that are believed to play an important role in defending the plant from invasion by pests and pathogens. These proteinaceous inhibitor molecules belong to a number of structurally distinct families. We describe here the isolation, ...
the unusual additional C-terminal exten-sion was observed in cysteine protease (Mottramet al. 1989),3-mercaptopyruvate sulfurtransferase (Williamset al. 2003)and now in oligopeptidase B-2 (this work). In the cysteineproteases, the C-terminal extension displays 100 amino acids.Some functions were ...
Intramolecular hydrogen bonding between the amino and dihydrofuran-2,5-dione group and clustering of the locked C=O groups from the POSS nanoparticles in the MIPOSS-NHBu units restricted the intramolecular motion of the polymer chain, causing it to exhibit strong light emission. As a result, ...
Blaskovich MA (2016) Unusual amino acids in medicinal chemistry. J Med Chem 59:10807–10836 Article CAS PubMed Google Scholar Cardillo G, Gentilucci L, Tolomelli A (2006) Unusual amino acids: synthesis and introduction into naturally occurring peptides and biologically active analogues. Mini-Re...