A widely used example of such a non-canonical amino acid is p-azido-L-phenylalanine (AzF), which can be used for protein interaction studies due to its photosensitivity13. Furthermore, AzF is known to selectively react under physiological conditions via a set of different reactions such as ...
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Through a combination of non-canonical amino acid incorporation, protein purification, and spectroscopic fluorescence techniques, this study reports on changes in conformational dynamics of SERT imposed by the binding of ions and ligands.Andreas Nygaard...
To participate in protein synthesis amino acids require attachment to transfer RNA molecules (tRNAs). This reaction is accomplished by aminoacyl-tRNA synthetases (AARSs), enzymes that use ATP to activate the matching amino acid and transfer it to the cognate tRNA, which, in turn, harbors the ...
Whereas nature relies on a small number of amino acid structures, chemists desire access to a vast range of structurally diverse analogues1,2,3. The selective modification of amino acid side-chain residues represents an efficient strategy to access non-canonical derivatives of value in chemistry ...
non-canonical amino acid, synthetic biosafety, post-translational modificationThe incorporation of noncanonical amino acids (ncAAs) has been extensively studied because of its broad applicability. In the past decades, various in vitro and in vivo ncAA incorporation approaches have been developed to ...
(Fig.2b). ncAA labeling can be designed to occur either at specific amino acid residues of interest, for example using a Methionine (Met) analog that carries an azide or alkyne functionality to replace any Met in a newly synthesized protein [3], or at specific sites in a protein of ...
Non-canonical Amino Acid Incorporation into 2,5-Diketopiperazines by Cyclodipeptide SynthasesCyclodipeptide synthasesDiketopiperazinesNatural product engineeringNon-canonical amino acidBiosynthesisThe manipulation of natural product biosynthetic pathways is a powerful means of expanding the chemical diversity of ...
This dissertation primarily describes investigations of the mechanisms by which pentameric ligand-gated ion channels (pLGICs) activate ("gating") using canonical and non-canonical amino acid mutagenesis. Chapter 1 provides an introduction to the systems being studied, their physiological roles, and the...
内容提示: Aminoacyl-tRNA synthetase inhibition activatesa pathway that branches from the canonicalamino acid response in mammalian cellsYeonjin Kim a,1 , Mark S. Sundrud b,1 , Changqian Zhou a , Maja Edenius a , Davide Zocco a , Kristen Powers a ,Miao Zhang a , Ralph Mazitschek...