Methods: This study investigates the immune manipulating effects of EVs, produced from the clinical cases and cell line of canine B cell lymphoma, on CD8 T-cells isolated from canine donors. Results: Lymphoma-derived EVs lead to the apoptosis of CD8 T-cells. Furthermore, EVs trigger the ...
Translational research can be furthered using tools such as canine cell lines to model therapeutic compounds and strategies. We developed 5 B-cell lymphoma cell lines from dogs with confirmed large B-cell lymphoma. These cell lines were CD3, CD18, CD20, and CD90 positive with variable CD79a,...
Characterization of spheres derived from canine mammary gland adenocarcinoma cell lines There is increasing evidence for the presence of cancer stem cells in several solid tumors, and these cancer stem cells have a potential role in tumor init... Masaki Michishita and Rui Akiyoshi and Hisashi Yoshim...
2016. Canine small clear cell/T-zone lymphoma: clinical presentation and outcome in a retrospective case series. Vet. Comp. Oncol. 14 Suppl 1: 117-126. [Medline] [CrossRef]Martini V, Marconato L, Poggi A, et al. Canine small clear cell/T- zone lymphoma: clinical presentation and...
In Lymphoma, the regulation of production is lost and these cells proliferate in large number, or they lose their programed life cycle and continue to live on, overwhelming the other blood cells. High white blood cell count and swollen lymph glands are the characteristic signs of this disease,...
Humans and their pet dogs are close, so close that they both develop a type of cancer called diffuse large B-cell lymphoma. In humans it's the most common lymphoma subtype while in dogs, it's one of the most common cancers in veterinary oncology. ...
Diffuse large B-cell lymphoma (DLBCL) is the most common haematopoietic tumour in dogs and recognized as clinical model for its human counterpart. Recently, neutrophil-to-lymphocyte (NLR) and lymphocyte-to-monocyte (LMR) ratios have been shown to predict time-to-progression (TTP) and lymphoma-...
cell death pathway. Clusterin is a functional tumor marker for the diagnosis of pediatric large cell lymphoma. Clusterin is activated in low pH. Clusterin is involved in the inhibition of NF-kappaB signaling through stabilization of IkappaBs thus results in suppression of tumor cell motility. N-...
Large cell lymphoma (experimental)bCallitrichids Malignant B-cell lymphoma (experimental)e Panine herpesvirus 1 Chimpanzee herpes Apes None Pongine herpesvirus 2 Orangutan herpes Gorilline herpesvirus 1 Gorilla herpes Macacine herpesvirus 4 Rhesus lymphocryptovirus Rhesus Subclinical infection commonCo...
We studied the cytolytic effect of NDV-MLS, a low virulence attenuated lentogenic strain, on a human large B-cell lymphoma cell line (SU-DHL-4), as well as on primary canine-derived B-cell lymphoma cells, and compared them to healthy peripheral blood mononuclear cells (PBMC) from both ...