Editorial: Canine lymphoma pathogenesis, diagnosis, prognosis and treatment: current and future perspectivesdoi:10.3389/fvets.2024.1442964Castiglioni, VittoriaSforna, Monicade Vries, CynthiaFrontiers in Veterinary Science
Identification of a candidate therapeutic antibody for treatment of canine B-cell lymphoma. Vet Immunol Immunopathol. 2015;164(3–4):148–59. Article CAS PubMed Google Scholar Jain S, Aresu L, Comazzi S, Shi J, Worrall E, Clayton J, Humphries W, Hemmington S, Davis P, Murray E, ...
The molecular mechanisms underlying spontaneous neoplastic transformation in cultured mammalian cells remain poorly understood, confounding recognition of parallels with the biology of naturally occurring cancer. The broad use of tumorigenic canine cell lines as research tools, coupled with the accumulation of...
Independent analyses for PAC, PAC metastasis and TCC revealed 1743, 3941 and 463 genes, respectively, differentially expressed in the cell lines relative to their original tissues (DEGs). While genes associated with tumor microenvironment were mostly downregulated in the cell lines, patient-specific EM...
canine nodal diffuse large B‐cell lymphomaclinical signsprognosissubstagesurvivaltreatment responseIn humans B﹕ymptoms refer to systemic symptoms of lymphoma such as fever, weight loss, and night sweats and influence the prognosis of patients. In canine lymphoma, substage B is used to describe ...
Cutaneous lymphoma and giant cell dermatosis have also been reported in FeLV positive cats.31 Feline herpes virus Feline herpes virus ulcerative dermatitis typically involves the dorsal muzzle, but lesions may extend to involve the nasal planum (Fig. 11). Cats do not have to have concurrent ...
Cancer is the leading cause of death in the geriatric dog population. Currently, the use of immune checkpoint inhibitors (ICIs) such as anti-CTLA4 antibodies has markedly improved the prognosis of several cancers in their advanced stages. However, ICIs t
Fine needle aspiration from the skin lesions showed a population of large lymphocytes and lymphoblasts, and was helpful in establishing the diagnosis antemortem. The post-mortem examination revealed epitheliotropic lymphoma with liver metastasis. Immunohistochemistry proved the T-cell origin both in the ...
Furthermore, there has been increasing evidence that COX-2 overexpression is associated with tumourigenesis [4], angiogenesis [5], resistance to apoptosis, cancer cell proliferation and metastasis [6],[7]. COX-2 protein expression has been associated with a poor prognosis in human breast cancer ...
These activity-based assays provide valuable information regarding prognosis and treatment monitoring in canine lymphoma and leukemia [35],[36]. A recent study on sera from dogs with solid tumors demonstrated that determination of sTK1 protein levels with immunochemical methods gave higher sensitivity ...