The success of treatment regimens promoting differentiation has not been explored for all acute myeloid leukemia (AML) subtypes. Here, the authors identify and characterize two lysine (K) deacetylase inhibitors promoting myeloid differentiation in all AML subtypes at low non-cytotoxic doses. ...
cancer patients33,34,35. Associations between AS events and prognosis of patients have been demonstrated in non-small cell lung cancer (NSCLC), adrenocortical carcinoma (AC), head and neck squamous cell carcinoma (HNSCC), and so on. Previous studies have demonstrated the role of several AS patt...
It is instructive to distinguish specific molecular typing for the treatment and prognosis determination of patients with BC. For example, TNBC patients are sensitive to chemotherapeutic agents but not endocrine therapy and TNBC patients are generally highly heterogeneous, tend to metastasize, and have a...
METHOD TO ASSESS PROGNOSIS AND TO PREDICT THERAPEUTIC SUCCESS IN CANCER BY DETERMINING HORMONE RECEPTOR EXPRESSION LEVELSThe present invention is related to a method of classifying a sample of a patient who suffers from or being at risk of developing cancer, said method comprising the steps of ...
Lung cancer is the primary cause of mortality in the United States and around the globe. Therapeutic options for lung cancer treatment include surgery, radiation therapy, chemotherapy, and targeted drug therapy. Medical management is often associated wit
RP1-85F18.6 results in GSDMD cleavage to trigger pyroptosis [115]. Moreover, another study revealed that lower GSDMD expression is associated with a poorer CRC prognosis; furthermore, increased GSDMD expression effectively induces cell death [116]. The activation of pyroptosis by upregulating IFN-...
surgical treatment is challenging, and repair is frequently required after resection. The prognosis for people with this type varies with disease stage and is typically poorer than with other melanoma subtypes. Patients with advanced ALM are being investigated for response to newer therapeutic modalities...
In recent decades, the advent of immune-based therapies, most notably Chimeric antigen receptor (CAR)-T cell therapy has revolutionized cancer treatment. The promising results of numerous studies indicate that CAR-T cell therapy has had a remarkable abil
Substantial progress has been made in using deep learning for cancer detection and diagnosis in medical images. Yet, there is limited success on prediction of treatment response and outcomes, which has important implications for personalized treatment st
treatment. Although the majority of studies on DDR have focused on the role of poly (ADP-ribose) polymerase (PARP), the development of resistance to PARP inhibitors is becoming increasingly problematic in clinical settings since resistance exacerbates disease recurrence and worsens patient prognosis. ...