CONTEXT: Increased 5-year survival for cancer patients is generally inferred to mean that cancer treatment has improved and that fewer patients die of cancer. Increased 5-year survival, however, may also reflect changes in diagnosis: finding more people with early-stage cancer, including some wh...
The success of treatment regimens promoting differentiation has not been explored for all acute myeloid leukemia (AML) subtypes. Here, the authors identify and characterize two lysine (K) deacetylase inhibitors promoting myeloid differentiation in all AML subtypes at low non-cytotoxic doses. ...
In the past 25 years, cancer survival rates in Australia have improved by 18%, and newly-diagnosed individuals on average now have a 70% chance of surviving cancer at least five years beyond their diagnosis. This success is largely due to improvements in public health initiatives, detection met...
Extensive effort has been devoted to increasing rates of success in oncology drug development by improving preclinical studies1,2,3. However, completed randomized controlled trials (RCTs) remain the most valuable single source of information for understanding opportunities and challenges in drug developmen...
WebMD's slideshow explains the symptoms, causes, treatments, and survival rates for cervical cancer. A close link to the human papillomavirus (HPV) offers a way to prevent many cases.
survival in untreated MSI-H/dMMR mGC patients [15]. Substantial breakthroughs in the treatment of gastric cancer have been achieved with novel anti-HER2 therapeutic agents, such as T-DXd and disitamab vedotin (RC48) [16]. In addition, in light of the success of immunotherapy and targeted ...
Treatment with Xtandi extended life by almost 5 months. https://www.drugs.com/medical-answers/long-xtandi-enzalutamide-work-3554743/ Lilly stomach cancer drug extends survival vs placebo The overall survival among patients treated with the Lilly drug in the study was 5.2 months, compared with 3.8...
Instead, the use of surrogate measures, such as progression-free survival (PFS) or response rates for drug approval decisions, has increased. These surrogate measures are known to poorly correlate with improvements in OS or QOL for most tumor types.7-10 For drugs that are associated with ...
Traditional therapeutic approaches such as chemotherapy and radiation therapy have burdened cancer patients with onerous physical and psychological challenges. Encouragingly, the landscape of tumor treatment has undergone a comprehensive and remarkable t
The incidence of cancer in reproductive-aged women is 7%, but, despite the increased number of cancer cases, advances in early diagnosis and treatment have raised the survival rate. Furthermore, in the last four decades, there has been a rising trend of delaying childbearing. There has been ...