This review is dealing with identification of cancer stem cell markers, their latest classification, function in normal and cancer stem cells (CSCs), and their use in development of novel targeted antitumor therapy. It was difficult to prove the CSC s existence, unless the in vivo and in ...
molecular markers with adult hepatocytes and fetal hepatocytes. In addition, markers frequently used to identify adult stem cells within the prostate, breast and intestine include CD44, CD133, ESA, CD69, p63, as well as some stem cell antigen, such as CD34, c-kit, Flt-3, NCAM, and Thy-...
将复发的小鼠肿瘤(即抵抗的)及敏感的的小鼠肿瘤再次种植到新的受体小鼠中,发现再次化疗对于耐药的肿瘤几乎没有任何效果,表明该小鼠模型较好的呈现了MIBC临床治疗反应以及化疗后的耐药表型。 并且,他们发现相比于敏感的肿瘤,在化学耐药的肿瘤中化疗抵抗相关的基因上调,同时鳞状细胞的markers丰度增加,表明药物抵抗的肿瘤开始...
Human breast cancer stem cell markers CD44 and CD24: Enriching for cells with functional properties in mice or in man? Identification of breast cancer stem cells as the cells within breast tumors that have the ability to give rise to cells that make up the bulk of the tumor... C Fillmore...
Introduction The lineages assumed by stem cells during hematopoiesis can be identified by the pattern of protein markers present on the surface of cells at different stages of differentiation. Specific antibodies directed at these markers have facilitated the isolation of hematopoietic stem cells by flow...
Dual staining of markers is the best method to present concurrent expression of markers on the same cells, as both OCT4 and NANOG markers are expressed on the nucleus and cytoplasm; however, we were unable to perform double staining with matched antibodies. Therefore, immunohistochemistry was perfo...
an interview with dr. fredika robertson novel protein expression assays using qpcr for the detection and relative quantification of protein markers in stem tools and strategies for rare-event detection using flow cytometry rapid detection of rare events literature downregulation of mirna-200c links ...
We suggest it might be useful to evaluate the presence of CSC markers, such as CD98, in addition to HPV-status, as a stratification marker. Consequently, patients with an HPV-positive OPSCC, but a high fraction of CD98-positive tumour cells, might better not be selected for de-escalating...
N. et al. Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Glia 39, 193–206 (2002). Article PubMed Google Scholar Hemmati, H. D. et al. Cancerous stem cells can arise from pediatric brain tumors. Proc. Natl Acad. Sci. ...
However, CSCs are few in number and lack unique surface markers to identify them, making targeted therapy difficult. Studies on CSCs to gain a greater understanding of theirbiologicalactivity and behavior in order to identify therapeutic targets are very important. The new methods related to these ...