a therapeutic agent for AML that target the LSC, as well as samples containing hematopoietic cells for allogeneic transplantation or autologous transplantation for AML patients A process for the preparation of, as an indicator LSC one marker, the manufacturing method comprising the steps of obtaining ...
A method for producing a sample containing hematopoietic cells for autogenous or allogenic transplantation into an AML patient, which comprises a step for obtaining an LSC-purged sample using at least one kind of LSC marker as an indicator. The aforesaid LSC marker genes are as defined in the ...
Higher expression of CD123+ cells on blasts and within CD34+ stem/progenitor cells correlated with poor prognosis cytogenetics (p=0.016 and 0.034) and unmutated NPM1 (p<0.001 and p=0.003, respectively). Altogether, 62.1% (59/95) pts achieved negative MRD, which in a multivariate analysis ...
Cell Stem Cell. 2015;17:341–52. Article CAS Google Scholar Jan M, Chao MP, Cha AC, Alizadeh AA, Gentles AJ, Weissman IL, et al. Prospective separation of normal and leukemic stem cells based on differential expression of TIM3, a human acute myeloid leukemia stem cell marker. Proc ...
Dipeptidyl peptidase-4, (DPP4; CD26) which cleaves diverse substrates such as chemokines and inhibits the stromal cell-derived factor-1 (SDF1; CXCL12). Cleaving the SDF1-CXCR4 axis by CD26 is implicated in releasing CML LSCs from the bone marrow into the blood and may be a marker ofchro...
CD133 is a positive marker for a distinct class of primitive human cord blood-derived CD34-negative hematopoietic stem cells 人CD34阴性(CD34-)造血干细胞(HSC)的发现进一步加深了我们对人HSC不同等级成员的了解。先前的研究表明,与特征明确的CD34+CD38− 严重联合免疫缺陷(SCID)繁殖细胞(SRC)相比,CD34- ...
T Cell Leukemia In subject area: Pharmacology, Toxicology and Pharmaceutical Science Adult T-cell leukemia/lymphoma (ATL) is an aggressive peripheral T cell lymphoma associated with human T cell lymphotropic virus Type-1 infection (HTLV-1).
although this marker is also found on other progenitor cell types such as multipotent mesenchymal stromal cells (MSCs). A common way to stain for these leukemic stem cells is the aberrant expression ofCD117(Figure 5), also called proto-oncogene c-Kit or stem cell growth factor receptor. CD11...
typically a marker for myeloid progenitors, remains highly expressed in AML as these cells do not undergo proper cell maturation. Additional markers such as CD14, CD16, CD64, and CD117 also show high sensitivity for the AML phenotype. Proteintech’s flow compatible CD33 antibody has been conjuga...
CD34+CD38− conventional phenotype is overall regarded as LSCs, but it has a limitation that is still hard to demarcate exactly due to similarity with normal hematopoietic stem cells (HSCs). Not all primary blasts and progenitors have equal function, thus a bona fide marker for identifying ...